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Flavonoid-rich Phyla nodiflora fraction promotes Keap1 degradation and Nrf2/HO-1 activation to attenuate particulate matter–induced oxidative stress in human keratinocytes

Bibliographic Data

ID14727710
AuthorsChia-Hsuan Lin (0000-0002-0898-2219, Kaohsiung Medical University), Jin-Ye Wu (Kaohsiung Medical University), Andrea Gu (Kaohsiung Medical University), Ho-Cheng Wu (Kaohsiung Medical University), Ho‐Cheng Wu (0000-0002-6648-6010, Kaohsiung Medical University), Yih-Fung Chen (Kaohsiung Medical University, corresponding author), Yih‐Fung Chen (0000-0002-5595-1319, Kaohsiung Medical University, corresponding author), Horng-Huey Ko (0000-0003-4203-0200, Kaohsiung Medical University, corresponding author)
Year2026
Volume360
Pages121168
Publication date2026-04-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2026.121168
PMID41494610
OpenAlexW7118123810
LanguageEN
References cited56

Antioxidant · Biological activity · Fraction (chemistry · KEAP1 · Oxidative damage · Oxidative phosphorylation · Oxidative stress · Genomics, phytochemicals, and oxidative stress · Phytochemicals and Antioxidant Activities · Skin Protection and Aging

  • Particulate matter exposure in construction sites is associated with health effects in workers

    Open Access•Eghbal Sekhavati, Reza Jalilzadeh Yengejeh•Frontiers in Public Health•2023

  • Resveratrol targeting NRF2 disrupts the binding between Keap1 and NRF2-DLG motif to ameliorate oxidative stress damage in mice pulmonary infection

    Open Access•Fuyun Chi, Chuanjing Cheng et al.•Journal of Ethnopharmacology•2024

  • Eupafolin ameliorates COX-2 expression and PGE2 production in particulate pollutants-exposed human keratinocytes through ROS/Mapks pathways

    Open Access•Chiang-Wen Lee, Chiang‐Wen Lee et al.•Journal of Ethnopharmacology•2016

  • Ethnopharmacological application of medicinal plants to cure skin diseases and in folk cosmetics among the tribal communities of North-West Frontier Province, Pakistan

    Open Access•Arshad Mehmood Abbasi, Mubarak Ali Khan et al.•Journal of Ethnopharmacology•2010

  • Eupafolin, a skin whitening flavonoid isolated from Phyla nodiflora, downregulated melanogenesis

    Open Access•Horng-Huey Ko, Horng‐Huey Ko et al.•Journal of Ethnopharmacology•2014

Citation velocityhistorical
Highly citedNo

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