The anti-colorectal cancer effect and metabolites of Agrimonia pilosa Ledeb

Bibliographic Data

ID14727799
AuthorsLixue Wang (0000-0001-9704-1527, Capital Medical University), Qijun Chen (0000-0003-0356-7435, Capital Medical University), Hui Song (0000-0002-0458-5136, Capital Medical University), Wen Xing (0009-0007-3569-1613), Xing Wen (0000-0001-7144-1784, Capital Medical University), Junfeng Shi (0000-0003-3950-4073, Capital Medical University), Yudi Li (0000-0002-7143-838X, Capital Medical University), Yunpeng Lv (Capital Medical University), Ziqian Wang (0000-0001-8113-9941, Capital Medical University), Jinlong Chen (0000-0003-0517-9268, Capital Medical University), Wenhua Zhao (0000-0003-4532-0078, Capital Medical University, corresponding author)
Year2024
Volume329
Pages118146
Publication date2024-07-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2024.118146
PMID38604512
OpenAlexW4394619847
LanguageEN
Citations received1
References cited29

The extract from root of A. pilosa showed anti-colorectal cancer effects in vivo and in vitro, affecting the composition of gut microbiota and the anti-tumor immune response. Within all components of A. pilosa, Agrimoniin and Agrimonolide-6-o-glucoside showed remarkable anti-CRC efficiency in vivo and in vitro. Besides, the metabolites of extract from root of A. pilosa in gastrointestinal tract mainly composed of two parts: Agrimonolide-related metabolites and Urolithins. The extract from root of A. pilosa could contribute to potential drugs for assisting clinical anti-colon cancer therapy

Bidens pilosa · Biology · Botany · Cancer · Colorectal cancer · Flow cytometry · In vivo · Traditional medicine · Colorectal Cancer Treatments and Studies · Genomics, phytochemicals, and oxidative stress · Medicine · Pharmacological Effects of Natural Compounds · Immunology · Pharmacology

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