Targeted metabolomics revealed the mechanisms underlying the role of Liansu capsule in ameliorating functional dyspepsia

Bibliographic Data

ID14727912
AuthorsJiashu Pan (0000-0002-8619-4015, Shanghai University of Traditional Chinese Medicine), Jiaxuan Wu (0000-0002-0443-6747, Shanghai University of Traditional Chinese Medicine), Shengan Zhang (0000-0001-6560-8808, Shanghai University of Traditional Chinese Medicine), Kai Wang (0000-0002-3784-1378, Shanghai University of Traditional Chinese Medicine), Guang Ji (0000-0003-0842-3676, Shanghai University of Traditional Chinese Medicine), Wenjun Zhou (0009-0004-3772-2653, Longhua Hospital Shanghai University of Traditional Chinese Medicine, corresponding author), Yanqi Dang (0000-0002-0316-7880, Longhua Hospital Shanghai University of Traditional Chinese Medicine, corresponding author)
Year2024
Volume321
Pages117568
Publication date2024-03-01
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2023.117568
PMID38092317
OpenAlexW4389570666
LanguageEN
Citations received1
References cited47

Our findings indicated that Liansu capsule improved FD by regulating the deoxycholic acid/hyodeoxycholic acid-TGR5-STAT3-KLF5 axis. The findings reveal a novel mechanism underlying the role of Liansu capsule, which may be a promising therapeutic strategy for FD

Bile acid · Biology · Capsule · Cytokine · Deoxycholic acid · Inflammation · Interleukin · Proinflammatory cytokine · Signal transduction · STAT protein · STAT3 · Tumor necrosis factor alpha · Gut microbiota and health · Helicobacter pylori-related gastroenterology studies · Medicine · Pharmacological Effects of Natural Compounds · Biochemistry · Endocrinology · Internal Medicine · Pharmacology

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