Antitumoral activity of different Amaryllidaceae alkaloids

In vitro and in silico assays

Bibliographic Data

ID14728017
AuthorsLuciana R Tallini (0000-0003-3890-0971, Universidade Federal do Rio Grande do Sul, corresponding author), Gustavo das Neves (0000-0002-2935-9944, Universidade Federal do Rio Grande do Sul), Maria Helena Vendruscolo (0000-0002-3254-7583, Universidade Federal do Rio Grande do Sul), Paula Rezende-Teixeira (0000-0003-4138-8040, Universidade de São Paulo), Warley Borges (0000-0003-4475-1028, Universidade Federal do Espírito Santo), Jaume Bastida (0000-0002-0294-5927, Universitat de Barcelona), Letícia V Costa-Lotufo, Letícia V Costa‐Lotufo (0000-0003-1861-5153, Universidade de São Paulo), Vera Lucia Eifler-Lima, Vera Eifler-Lima (0000-0002-7656-9477, Universidade Federal do Rio Grande do Sul), José Ângelo Silveira Zuanazzi (0000-0003-1506-6355, Universidade Federal do Rio Grande do Sul, corresponding author)
Year2024
Volume329
Pages118154
Publication date2024-07-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2024.118154
PMID38614259
OpenAlexW4394770177
LanguageEN
References cited58

In vitro and in silico results corroborate with data literature suggesting the Amaryllidaceae alkaloids as interesting molecules with antitumoral properties, especially montanine, which showed the best in vitro results against colorectal and breast carcinoma. More studies are necessary to confirm the targets and pharmaceutical potential of montanine against these cancer cell lines

Alkaloid · Amaryllidaceae · Amaryllidaceae Alkaloids · Biology · Botany · Docking (animal · In silico · In vitro · Lycorine · Stereochemistry · Alkaloids: synthesis and pharmacology · Chemical synthesis and alkaloids · Chemistry · Medicine · Psychedelics and Drug Studies · Biochemistry

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