Valeriana jatamansi jones improves depressive behavior in Cums mice by modulating vitamin B12-related ileal homeostasis
Bibliographic Data
| ID | 14728162 |
|---|---|
| Authors | Pengcheng Lv (0000-0002-6127-8781), Fang Xiang (0000-0002-2808-9671, Southwest Jiaotong University), Fangrui Xiang, Shengqi Zhang (0009-0008-9208-6724, Southwest Jiaotong University), Dongni Lei, Shen Lei (0000-0003-1019-5481, Southwest Jiaotong University), Chaomeng Zhou, Cui Zhou (0000-0002-8523-1064, Southwest Jiaotong University), Guihua Wei (0009-0000-1234-4095, Southwest Jiaotong University), Zhiyong Yan (0000-0003-3596-9463, Southwest Jiaotong University, corresponding author) |
| Year | 2025 |
| Volume | 342 |
| Pages | 119392 |
| Publication date | 2025-02-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2025.119392 |
| PMID | 39875065 |
| OpenAlex | W4406829059 |
| Language | EN |
| References cited | 30 |
These findings suggest that the mechanism of V. jatamansi in treating depression may be through repairing depression-associated intestinal damage. This repair process may affect the intestinal absorption and microbial production of B12. By reversing the reduction of serum B12, V. jatamansi ultimately reduces the infiltration of Hcy into the CNS
Biology · Homeostasis · Vitamin B12 · Chemistry · Child Nutrition and Feeding Issues · Eating Disorders and Behaviors · Medicinal Plant Extracts Effects · Medicine · Neuroscience · Endocrinology · Pharmacology
| Citation velocity | historical |
|---|---|
| Highly cited | No |