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Combining network pharmacology and transcriptomics to validate and explore Shenqiyichang decoction in treating colorectal cancer by NQO1 inhibition, ROS activation and Wnt/β-catenin signaling pathway

Bibliographic Data

ID14728422
AuthorsWen Cao (0009-0009-1225-8678, Nanjing University of Chinese Medicine), Zhou Zhou (0000-0001-9906-8889, Nanjing University of Chinese Medicine), Lingchang Li (0000-0001-5520-7023, Nanjing University of Chinese Medicine), Jialin Yu (0000-0001-9349-1766, Nanjing University of Chinese Medicine), Wenyu Li (0000-0003-0218-589X, Jiangsu Cancer Hospital), Xueping Xia (Nanjing University of Chinese Medicine), Shan Deng (0000-0001-6763-8381, Nanjing University of Chinese Medicine, corresponding author), Jiege Huo (0000-0002-0463-134X, Nanjing University of Chinese Medicine, corresponding author)
Year2026
Volume364
Pages121474
Publication date2026-06-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2026.121474
PMID41786058
OpenAlexW7133315254
LanguageEN
References cited18

Apoptosis · Colorectal cancer · Cyclin D1 · Gene knockdown · In vivo · KEGG · Signal transduction · Transcriptome · Bioactive Compounds and Antitumor Agents · Genomics, phytochemicals, and oxidative stress · Wnt/β-catenin signaling in development and cancer

  • Network pharmacology analysis, molecular docking integrated experimental verification reveal β-sitosterol as the active anti-NSCLC ingredient of Polygonatum cyrtonema Hua by suppression of PI3K/Akt/HIF-1α signaling pathway

    Open Access•Wen Cao, Fangwei Yuan et al.•Journal of Ethnopharmacology•2024

  • Jingfang Granule promotes the tricarboxylic acid cycle to improve chronic fatigue syndrome by increasing the expression of Idh1 and Idh2

    Open Access•Kun Wang, Mengmeng Shen et al.•Journal of Ethnopharmacology•2025

  • Akebia trifoliata (Thunb.) Koidz Seed Extract inhibits human hepatocellular carcinoma cell migration and invasion in vitro

    Open Access•Wen-Li Lu, Wenli Lu et al.•Journal of Ethnopharmacology•2019

Citation velocityhistorical
Highly citedNo

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