Combining network pharmacology and transcriptomics to validate and explore Shenqiyichang decoction in treating colorectal cancer by NQO1 inhibition, ROS activation and Wnt/β-catenin signaling pathway
Bibliographic Data
| ID | 14728422 |
|---|---|
| Authors | Wen Cao (0009-0009-1225-8678, Nanjing University of Chinese Medicine), Zhou Zhou (0000-0001-9906-8889, Nanjing University of Chinese Medicine), Lingchang Li (0000-0001-5520-7023, Nanjing University of Chinese Medicine), Jialin Yu (0000-0001-9349-1766, Nanjing University of Chinese Medicine), Wenyu Li (0000-0003-0218-589X, Jiangsu Cancer Hospital), Xueping Xia (Nanjing University of Chinese Medicine), Shan Deng (0000-0001-6763-8381, Nanjing University of Chinese Medicine, corresponding author), Jiege Huo (0000-0002-0463-134X, Nanjing University of Chinese Medicine, corresponding author) |
| Year | 2026 |
| Volume | 364 |
| Pages | 121474 |
| Publication date | 2026-06-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2026.121474 |
| PMID | 41786058 |
| OpenAlex | W7133315254 |
| Language | EN |
| References cited | 18 |
Apoptosis · Colorectal cancer · Cyclin D1 · Gene knockdown · In vivo · KEGG · Signal transduction · Transcriptome · Bioactive Compounds and Antitumor Agents · Genomics, phytochemicals, and oxidative stress · Wnt/β-catenin signaling in development and cancer
Network pharmacology analysis, molecular docking integrated experimental verification reveal β-sitosterol as the active anti-NSCLC ingredient of Polygonatum cyrtonema Hua by suppression of PI3K/Akt/HIF-1α signaling pathway
Jingfang Granule promotes the tricarboxylic acid cycle to improve chronic fatigue syndrome by increasing the expression of Idh1 and Idh2
Akebia trifoliata (Thunb.) Koidz Seed Extract inhibits human hepatocellular carcinoma cell migration and invasion in vitro
| Citation velocity | historical |
|---|---|
| Highly cited | No |