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Phytochemical profiling and system-level mechanistic insights into the anti-arthritic activity of Barleria cristata

Evidence from in-silico network pharmacology, molecular docking, in-vitro and in-vivo studies

Bibliographic Data

ID14728786
AuthorsSubhasish Sahoo (0000-0002-2673-8789, Siksha O Anusandhan University), Sandesh Kumar Pattanaik (0009-0000-5441-4637, Siksha O Anusandhan University), Paresh Kumar Barad (Siksha O Anusandhan University), Jyoti Ranjan Mahapatra (Siksha O Anusandhan University), Sandip Kumar Acharya (Siksha O Anusandhan University), Sovan Pattanaik (0000-0003-4610-6647, Siksha O Anusandhan University), Diptirani Rath (0000-0002-6840-084X, Siksha O Anusandhan University, corresponding author)
Year2026
Volume364
Pages121517
Publication date2026-06-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2026.121517
PMID41831742
OpenAlexW7135077706
LanguageEN
References cited40

Gene expression profiling · Pharmacognosy · Phytochemical · Profiling (computer programming · Computational Drug Discovery Methods · Phytochemistry and Biological Activities · Quinazolinone synthesis and applications

  • Exploring anti-diabetic activity of Caryota mitis Lour. through modulation of PPAR- α/γ, GLUT-4, using in-vitro, in-vivo and in-silico approaches

    Open Access•Sandesh Kumar Pattanaik, Sovan Pattanaik et al.•Journal of Ethnopharmacology•2025

  • Extracts and pimaradienoic acid from Eleutherococcus trifoliatus L. S. Y. Hu for the treatment of Rheumatoid Arthritis by modulating NF-κB signaling pathway

    Open Access•Siyu Zhao, Bingyi Xu et al.•Journal of Ethnopharmacology•2026

  • Hepatoprotective potency of Litsea glutinosa (L.) C.B. Rob. leaf methanol extract on H2O2-induced toxicity in HepG2 cells

    Open Access•Subhasish Sahoo, Diptirani Rath et al.•Journal of Ethnopharmacology•2023

  • Inula viscosa (L). Aiton leaves extract ameliorate arthritis by antioxidative and anti-inflammatory effects in formaldehyde-induced arthritis in mice

    Open Access•Sara Ouari, Nadia Benzidane et al.•Journal of Ethnopharmacology•2025

  • Protective effect of Tecoma stans (L.) Juss.ex Kunth in CFA-induced arthritic rats

    Open Access•Chandan Das, Pritam Kar et al.•Journal of Ethnopharmacology•2025

  • Mesua assamica (King & Prain) kosterm. bark ethanolic extract attenuates rheumatoid arthritis via down-regulating TLR4/NF-κB/COX-2/iNOS and activation of Nrf2/HO-1 pathways

    Open Access•Eswara Rao Puppala, Neethu Prasad et al.•Journal of Ethnopharmacology•2024

  • Crateva magna (Lour.) DC ameliorates rheumatoid arthritis via TNF-signalling pathways

    Open Access•Sandesh Kumar Pattanaik, Subhasish Sahoo et al.•Journal of Ethnopharmacology•2025

  • Dictamnus dasycarpus turcz. Attenuates collagen-induced rheumatoid arthritis in DBA/1J mice through inhibiting IL-17 signaling pathway

    Open Access•Yan Liu, Luxin Li et al.•Journal of Ethnopharmacology•2025

  • Anti-rheumatoid arthritis potential of Rhododendron molle G. Don leaf extract in adjuvant induced arthritis rats

    Open Access•Yuqiang Luo, Yu Shen et al.•Journal of Ethnopharmacology•2023

  • Ermiao San attenuating rheumatoid arthritis via PI3K/AKT/mTOR signaling activate HIF-1α induced glycolysis

    Open Access•Yumeng Zhang, Haizhu Jin et al.•Journal of Ethnopharmacology•2025

  • Component identification of modified sanmiao pills by UPLC-Xevo G2-XS QTOF and its anti-gouty arthritis mechanism based on network pharmacology and experimental verification

    Open Access•Ruyi Chen, Fenfen Li et al.•Journal of Ethnopharmacology•2023

  • Antidiabetic effects of Cuscuta reflexa Roxb. in streptozotocin induced diabetic rats

    Open Access•Diptirani Rath, Durga Madhab Kar et al.•Journal of Ethnopharmacology•2016

  • Medicinal plant diversity of Sitamata wildlife sanctuary, Rajasthan, India

    Open Access•Anita Jain, S S Katewa et al.•Journal of Ethnopharmacology•2005

  • Ephedra gerardiana aqueous ethanolic extract and fractions attenuate Freund Complete Adjuvant induced arthritis in Sprague Dawley rats by downregulating PGE2, COX2, IL-1β, IL-6, TNF-α, NF-kB and upregulating IL-4 and IL-10

    Open Access•Ambreen Malik Uttra, Alamgeer Alamgeer et al.•Journal of Ethnopharmacology•2018

  • Anti-rheumatic arthritis efficacy of Pueraria montana extract against type-II collagen-induced rheumatoid arthritis rat model an in vitro and in vivo assessment

    Open Access•Fangming Wang, Minli Liu et al.•Journal of Ethnopharmacology•2025

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