Chaihu-Shugan-San alleviates functional dyspepsia by inhibiting central sensitization and regulating glutamate metabolism via NMDAR/CaMKII signaling pathway

Bibliographic Data

ID14728870
AuthorsYuebo Jia (0000-0002-7419-9214, Shanghai University of Traditional Chinese Medicine), Chang Liu (0000-0002-1198-6990, Shanghai University of Traditional Chinese Medicine), Qingling Jia (0000-0002-8924-4073, Shanghai University of Traditional Chinese Medicine), Jing Wang (0000-0002-7594-8539, Shanghai University of Traditional Chinese Medicine), Yi Quan (0000-0002-5875-1304, Shanghai University of Traditional Chinese Medicine), Xinyuan Li (0000-0001-8758-5301, Shanghai University of Traditional Chinese Medicine), Chenheng Wu (Shanghai University of Traditional Chinese Medicine, corresponding author), Jianghong Ling (0000-0001-7550-9694), Jiajie Ling (Shanghai University of Traditional Chinese Medicine, corresponding author)
Year2026
Volume360
Pages121201
Publication date2026-04-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2026.121201
PMID41544723
OpenAlexW7124285257
LanguageEN
References cited38

These findings demonstrate that CSS ameliorates FD by inhibiting central sensitization - related activity and modulating glutamate metabolism, potentially mediated by the NMDAR/CaMKII signaling pathway

Cell Signaling · Central nervous system · Glutamate receptor · Metabolism · Sensitization · Signal transduction · Gastrointestinal motility and disorders · Traditional Chinese Medicine Analysis · Ziziphus Jujuba Studies and Applications

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