Buzhong Yiqi decoction improves inflammation and oxidative damage in autoimmune thyroiditis by inhibiting apoptosis via the Sirt1-Mediated Nrf2/NF-κB axis

Bibliographic Data

ID14729147
AuthorsZhuo Zhao (0000-0001-9339-1896, Liaoning University of Traditional Chinese Medicine), Jiayun Li (0000-0003-3957-3538, Liaoning University of Traditional Chinese Medicine), Nan Song (0000-0001-6542-1488, Liaoning University of Traditional Chinese Medicine), Hao Gao (0000-0003-0148-3713, Liaoning University of Traditional Chinese Medicine), Dong Liu (0000-0001-9090-5732, Liaoning University of Traditional Chinese Medicine), Donglin Liu (0009-0001-8413-0202), Zhe Jin (0000-0001-7911-7970), Zhe Wu Jin (0000-0002-6789-2977, Liaoning University of Traditional Chinese Medicine), Yiran Chen (0000-0002-4612-3140, Liaoning University of Traditional Chinese Medicine), Xuanlin Guo, Xinlu Guo (Liaoning University of Traditional Chinese Medicine), Ziyu Liu (0009-0006-9435-4011, Liaoning University of Traditional Chinese Medicine, corresponding author), Xiao Yang (0009-0009-6059-6081, Liaoning University of Traditional Chinese Medicine, corresponding author)
Year2025
Volume351
Pages119967
Publication date2025-07-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2025.119967
PMID40360040
OpenAlexW4410266151
LanguageEN
References cited36

The findings from this study establish that BZYQ exhibits potent antioxidant and anti-inflammatory activities via the SIRT1-mediated Nrf2/NF-κB p65 axis, reducing thyroid cell apoptosis. These observations unveil a novel mechanism and support the potential of BZYQ as a promising therapeutic agent for AIT

Apoptosis · Autoimmune thyroiditis · Autoimmunity · Decoction · Immune system · Inflammation · NF-κB · Thyroid · Thyroiditis · Traditional medicine · Chemistry · Genomics, phytochemicals, and oxidative stress · Medicinal Plants and Bioactive Compounds · Medicine · Pharmacological Effects of Natural Compounds · Biochemistry · Endocrinology · Immunology · Pharmacology

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