Pterosin sesquiterpenoids from Pteris laeta Wall. ex Ettingsh. protect cells from glutamate excitotoxicity by modulating mitochondrial signals

Bibliographic Data

ID14729257
AuthorsAifang Cheng (0000-0002-5022-418X, Hong Kong University of Science and Technology), Yan Zhang (0000-0001-8460-2671, Hong Kong Baptist University), Jin Sun (0000-0002-7494-3963, Ocean University of China), Duli Huang (Hong Kong University of Science and Technology), Jordy Evan Sulaiman (0000-0002-0886-8707, Hong Kong University of Science and Technology), Xin Huang (0009-0007-5355-1008, Hong Kong University of Science and Technology), Long Wu (0000-0002-6696-2486, Hong Kong University of Science and Technology), Wenkang Ye (0000-0002-4042-695X, Shenzhen University), Chuanhai Wu (0000-0003-3123-0573, Hong Kong University of Science and Technology), Henry Lam (0000-0001-7928-0364, Hong Kong University of Science and Technology), Yusheng Shi (0000-0001-7256-3628), Yu-Sheng Shi (0000-0002-8474-4335, Dalian Medical University, corresponding author), Pei-Yuan Qian, Peiyuan Qian (0000-0003-4074-9078, Hong Kong University of Science and Technology, corresponding author)
Year2023
Volume308
Pages116308
Publication date2023-05-01
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2023.116308
PMID36822346
OpenAlexW4321438851
LanguageEN
References cited59

Our work revealed that pterosin B protected cells from glutamate excitotoxicity by targeting the downstream mitochondrial signals, making it a valuable candidate for developing potential therapeutic agents in treating neurodegenerative diseases

Apoptosis · Biology · Excitotoxicity · Gene · Gene expression · KEGG · Neuroprotection · Programmed cell death · Transcriptome · Western blot · Natural product bioactivities and synthesis · Plant Toxicity and Pharmacological Properties · Sesquiterpenes and Asteraceae Studies · Biochemistry · Cell Biology · Pharmacology

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