YuPingFeng (YPF) upregulates caveolin-1 (CAV1) to alleviate pulmonary fibrosis through the TGF-β1/Smad2 pathway
Bibliographic Data
| ID | 14729931 |
|---|---|
| Authors | Xiaohong Chen (0000-0003-0809-5297, Qilu Hospital of Shandong University), Xiao Chen (0000-0001-5474-0205), Min Wei (0000-0002-3131-0955, Taian City Central Hospital), Guodong Li (0000-0003-3137-8471, Taian City Central Hospital), Guo-Dong Li, Qi-Liang Sun (Taian City Central Hospital), Jia-Qi Fan, Jiaqi Fan (0009-0009-9095-007X, Jining Medical University), Junyi Li (0009-0007-3063-8565, Second Affiliated Hospital of Nanchang University), Jun-Yi Li, Chun-Mei Yun (Taian City Central Hospital), Dao-Ming Liu, Daoming Liu (0000-0002-2091-7081, Taian City Central Hospital), Hong Shi (0000-0002-3491-6127, Taian City Central Hospital), Yi-Qing Qu (0000-0002-9538-7601, Qilu Hospital of Shandong University, corresponding author) |
| Year | 2024 |
| Volume | 319 |
| Issue | Pt 3 |
| Pages | 117357 |
| Publication date | 2024-01-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2023.117357 |
| PMID | 37898439 |
| OpenAlex | W4387967210 |
| Language | EN |
| Citations received | 1 |
| References cited | 38 |
Network pharmacology analysis revealed that YPF exhibits significant potential as a therapeutic intervention for pulmonary fibrosis by targeting various compounds and pathways. This study emphasizes that the efficacy of YPF in treating pulmonary fibrosis may be attributed to its ability to up-regulate CAV1 expression and inhibiting pulmonary fibrosis via modulation of the TGF-β1/Smad2 signaling pathway. These findings underscore the promising role of YPF and its ability to potentially alleviate pulmonary fibrosis
Biology · Bleomycin · Calycosin · Fibrosis · Pathology · Pulmonary fibrosis · Systems pharmacology · Traditional Chinese medicine · Caveolin-1 and cellular processes · Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis · Medicine · Myeloproliferative Neoplasms: Diagnosis and Treatment · Cancer Research · Genetics · Internal Medicine · Pharmacology
Metascape provides a biologist-oriented resource for the analysis of systems-level datasets
Traditional Chinese medicine network pharmacology: theory, methodology and application
Development of an SPE–HPLC–MS method for simultaneous determination and pharmacokinetic study of bioactive constituents of Yu Ping Feng San in rat plasma after oral administration
| Citations per year | 1 |
|---|---|
| Citation span | 2026 - 2026 (1) |
| Highly cited | No |