Screening for bioactive secondary metabolites in Sri Lankan medicinal plants by microfractionation and targeted isolation of antimicrobial flavonoids from Derris scandens
Bibliographic Data
| ID | 14730240 |
|---|---|
| Authors | Supun Mohotti (University of Colombo), Sanjeevan Rajendran (0000-0002-7351-805X, University of Colombo), Taj Muhammad (0000-0002-6636-5809, Uppsala University), Adam A Strömstedt (0000-0001-9070-6944, Uppsala University), Achyut Adhikari (0000-0003-3778-8754, Tribhuvan University), Robert Burman (0000-0002-2341-1158, Uppsala University), E D de Silva (University of Colombo), Ulf Göransson (0000-0002-5005-9612, Uppsala University), C M Hettiarachchi, Chamari Hettiarachchi (0000-0002-9557-751X, University of Colombo), Sunithi Gunasekera (0000-0002-1089-4015, Uppsala University, corresponding author) |
| Year | 2020 |
| Volume | 246 |
| Pages | 112158 |
| Publication date | 2020-01-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2019.112158 |
| PMID | 31421182 |
| OpenAlex | W2967872865 |
| Language | EN |
| Citations received | 2 |
| References cited | 59 |
The microfractionation protocol developed in this study enabled time-efficient screening of many plants species, using a small quantity of sample material. In addition, microfractionation served as a guiding tool for identifying individual antimicrobial compounds. Through this process, flavonoids were isolated from Derris scandens, out of which dalpanitin and vicenin-3 showed activity in the low micromolar range. The high hit rate for in vitro antibacterial properties from this ethnopharmacologically guided sample collection gives credence to Sri Lankan traditional herbal medicine as a source for drug discovery
Antimicrobial · Bacillus cereus · Bacteria · Biology · Broth microdilution · Medicinal plants · Minimum inhibitory concentration · Traditional medicine · Bioactive natural compounds · Ethnobotanical and Medicinal Plants Studies · Medicine · Natural product bioactivities and synthesis · Microbiology
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| Unique citing works | 2 |
|---|---|
| Citations per year | 0,4 |
| Citation span | 2021 - 2024 (4) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 1 |