Network pharmacology integrated with experimental validation revealed the mechanism of Fengshi Gutong Capsule in the treatment of osteoarthritis
Bibliographic Data
| ID | 14730690 |
|---|---|
| Authors | Yanqiu Sun (0000-0002-2944-3708, Anhui University of Traditional Chinese Medicine), Jian Liu (0000-0002-1447-0973, Anhui University of Traditional Chinese Medicine, corresponding author), Jue Wang (0000-0002-6305-4298, China National Pharmaceutical Group Corporation (China)), Mingyu He (0000-0002-7047-8910, Anhui University of Traditional Chinese Medicine), Xiaolu Chen (0000-0002-5487-7882, Anhui University of Traditional Chinese Medicine), Li Chen (0000-0002-8432-3338, Anhui University of Traditional Chinese Medicine) |
| Year | 2024 |
| Volume | 319 |
| Issue | Pt 1 |
| Pages | 117261 |
| Publication date | 2024-01-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2023.117261 |
| PMID | 37788787 |
| OpenAlex | W4387232171 |
| Language | EN |
| References cited | 50 |
FSGTC alleviates the inflammatory response in patients with OA. This therapeutic effect was attributed to its anti-inflammatory and antioxidant properties, and its ability to promote IL-1β-induced chondrocyte proliferation, inhibit apoptosis, and prevent the degradation of extracellular matrix. These favorable results were associated with the inhibition of the PI3K/AKT, NF-κB, and JAK2/STAT3 signaling pathways
Apoptosis · Berberine · Biology · Cytokine · Janus kinase · Janus kinase 2 · Kinase · Osteoarthritis · Pathology · PI3K/AKT/mTOR pathway · Protein kinase B · Receptor · Signal transduction · STAT protein · STAT3 · Traditional Chinese medicine · Inflammatory mediators and NSAID effects · Medicine · Natural product bioactivities and synthesis · Osteoarthritis Treatment and Mechanisms · Biochemistry · Internal Medicine · Pharmacology
Calycosin mitigates chondrocyte inflammation and apoptosis by inhibiting the PI3K/AKT and NF-κB pathways
Efficacy and safety of Fengshi Gutong Capsule in patients with active ankylosing spondylitis
Study on the alleviation of Fengshi Gutong capsule on rheumatoid arthritis through integrating network pharmacology and experimental exploration
Traditional herbal medicine
Loganin ameliorates cartilage degeneration and osteoarthritis development in an osteoarthritis mouse model through inhibition of NF-κB activity and pyroptosis in chondrocytes
| Citation velocity | historical |
|---|---|
| Highly cited | No |