A review on the ethnobotany, phytochemistry, pharmacology and toxicology of butterbur species (Petasites L.)
Bibliographic Data
| ID | 14730771 |
|---|---|
| Authors | Łukasz Kulinowski (0000-0002-6811-5424, Medical University of Lublin), Simon Vlad Luca (0000-0003-0904-0060, Technical University of Munich, corresponding author), Mirjana Minceva (0000-0001-9820-7410, Technical University of Munich), Krystyna Skalicka-Woźniak (0000-0002-9313-5929, Medical University of Lublin, corresponding author) |
| Year | 2022 |
| Volume | 293 |
| Pages | 115263 |
| Publication date | 2022-07-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2022.115263 |
| PMID | 35427728 |
| OpenAlex | W4223593845 |
| Language | EN |
| References cited | 172 |
ETHNOPHARMACOLOGICAL RELEVANCE: Petasites (butterbur, Asteraceae) species have been used since Ancient times in the traditional medicine of Asian and European countries to treat central nervous system (migraine), respiratory (asthma, allergic rhinitis, bronchitis, spastic cough), cardiovascular (hypertension), gastrointestinal (ulcers) and genitourinary (dysmenorrhea) disorders. AIM OF THE REVIEW: This study summarized and discussed the traditional uses, phytochemical, pharmacological and toxicological aspects of Petasites genus. MATERIALS AND METHODS: A systematic search of Petasites in online databases (Scopus, PubMed, ScienceDirect, Google Scholar) was performed, with the aim to find the phytochemical, toxicological and bioactivity studies. The Global Biodiversity Information Facility, Plants of the World Online, World Flora Online and The Plant List databases were used to describe the taxonomy and geographical distribution. RESULTS: The detailed phytochemistry of the potentially active compounds of Petasites genus (e.g. sesquiterpenes, pyrrolizidine alkaloids, polyphenols and essential oils components) was presented. The bioactivity studies (cell-free, cell-based, animal, and clinical) including the traditional uses of Petasites (e.g. anti-spasmolytic, hypotensive, anti-asthmatic activities) were addressed and followed by discussion of the main pharmacokinetical and toxicological issues related to the administration of butterbur-based formulations. CONCLUSIONS: This review provides a complete overview of the Petasites geographical distribution, traditional use, phytochemistry, bioactivity, and toxicity. More than 200 different sesquiterpenes (eremophilanes, furanoeremophilanes, bakkenolides), 50 phenolic compounds (phenolic acids, flavonoids, lignans) and volatile compounds (monoterpenes, sesquiterpenes) have been reported within the genus. Considering the phytochemical complexity and the polypharmacological potential, there is a growing research interest to extend the current therapeutical applications of Petasites preparations (anti-migraine, anti-allergic) to other human ailments, such as central nervous system, cardiovascular, malignant or microbial diseases. This research pathway is extremely important, especially in the recent context of the pandemic situation, when there is an imperious need for novel drug candidates
Biological activity · Biology · Ethnobotany · Medicinal plants · Pharmacognosy · Phytochemistry · Traditional medicine · Botanical Research and Chemistry · Medicinal plant effects and applications · Medicine · Plant Toxicity and Pharmacological Properties · Toxicology
Suppressive effect of Petasites japonicus extract on ovalbumin-induced airway inflammation in an asthmatic mouse model
Petatewalide B, a novel compound from Petasites japonicus with anti-allergic activity
Anti-allergic and anti-inflammatory effects of bakkenolide B isolated from Petasites japonicus leaves
| Highly cited | No |
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