The integration strategy of Didang decoction against cerebral ischemia-reperfusion injury

Regulation of apoptosis-autophagy-inflammation network and validation of PI3K/Akt pathway

Bibliographic Data

ID14730775
AuthorsZhi-guang Song (0009-0006-7824-3565, Hunan University of Traditional Chinese Medicine, corresponding author), Yansong Liu (0009-0004-5913-0931, Hunan University of Traditional Chinese Medicine), Yan-song Liu, Si-si Dai (0009-0002-7143-9160, Hunan University of Traditional Chinese Medicine), Shu-ting Yin, Shuting Yin (0000-0002-3242-0996, Hunan University of Traditional Chinese Medicine), Yi-di Zeng, Yidi Zeng (Department of Science and Technology of Hunan Province), Yuchen Liu (0009-0000-2336-8092, Hunan University of Traditional Chinese Medicine), Yu-Chen Liu, Jiyong Liu (0000-0003-0444-957X, Hunan University of Traditional Chinese Medicine), Ji-yong Liu, Jin-xia Li (0000-0002-0949-8365, Hunan University of Traditional Chinese Medicine), Yu-yan Long, Yun Long (0000-0003-4228-8471, Hunan University of Traditional Chinese Medicine), Yu-jing Feng, Yujing Feng (Department of Science and Technology of Hunan Province), Hao-bo Jiang, Hao‐Bo Jiang (0000-0003-0190-4397, Hunan University of Traditional Chinese Medicine), Kun Lian (0000-0001-7557-9967, Hunan University of Traditional Chinese Medicine), Kai-ni Mao, K Mao (0009-0002-7298-5841, Department of Science and Technology of Hunan Province), Cai-xing Zheng (0009-0008-3990-3318, Hunan University), Li-hua Lin, Lihua Lin (0000-0003-0079-3939, Hunan University of Traditional Chinese Medicine), Zheyuan Zhang (0009-0005-8086-497X, Hunan University of Traditional Chinese Medicine), Zhe-yuan Zhang, Wei Yu (0000-0003-1933-5380, Hunan University of Traditional Chinese Medicine), Wen-lu Yu, Hua Li (0000-0002-1778-8071, Hunan University of Traditional Chinese Medicine), Wang-hua Liu (0009-0001-4877-7930), Wang‐Hua Liu (Hunan University of Traditional Chinese Medicine)
Year2025
Volume353
IssuePt A
Pages120277
Publication date2025-09-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2025.120277
PMID40645539
OpenAlexW4412391843
LanguageEN
References cited75

For the first time, this study systematically revealed the molecular mechanism by which Didang Decoction synergistically modulates metabolic networks and alleviates cerebral ischemia-reperfusion injury via multiple components

Apoptosis · Biology · Blood stasis · Decoction · Inflammation · Ischemia · Neuroprotection · Pathology · PI3K/AKT/mTOR pathway · Reperfusion injury · Stroke (engine · Traditional Chinese medicine · Traditional medicine · Ginseng Biological Effects and Applications · Medicine · Metabolomics and Mass Spectrometry Studies · Traditional Chinese Medicine Analysis · Biochemistry · Internal Medicine · Pharmacology

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