Rheinanthrone, a metabolite of sennoside A, triggers macrophage activation to decrease aquaporin-3 expression in the colon, causing the laxative effect of rhubarb extract
Bibliographic Data
| ID | 14732144 |
|---|---|
| Authors | Risako Kon (Ebara (Japan)), Nobutomo Ikarashi (0000-0001-6991-2946, Hoshi University), Chika Nagoya (Hoshi University), Tomoko Takayama (0000-0001-8150-3272, Hoshi University), Yoshiki Kusunoki (0000-0002-9361-9317, Ebara (Japan)), Makoto Ishii (0000-0003-4396-1664, Ebara (Japan)), Harumi Ueda (Hoshi University), Wataru Ochiai (0000-0002-4267-2521, Ebara (Japan)), Yoshiaki Machida (0000-0002-8449-0558, Hoshi University), Kazuyuki Sugita (0000-0001-6490-7259, Hoshi University), Kiyoshi Sugiyama (0000-0001-5558-9906, Hoshi University, corresponding author) |
| Year | 2014 |
| Volume | 152 |
| Issue | 1 |
| Pages | 190-200 |
| Publication date | 2014-02-01 |
| Peer Reviewed | Yes |
| Open Access | No |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2013.12.055 |
| PMID | 24412547 |
| OpenAlex | W2042293357 |
| Language | EN |
| Citations received | 9 |
| References cited | 38 |
Aquaporin · Aquaporin 3 · Biology · Constipation · Diarrhea · Laxative · Metabolite · Prostaglandin E2 · Chemistry · Gastrointestinal motility and disorders · Ion Transport and Channel Regulation · Medicine · Phytochemistry and biological activity of medicinal plants · Biochemistry · Internal Medicine · Pharmacology
Gangjihwan, a polyherbal composition, inhibits fat accumulation through the modulation of lipogenic transcription factors SREBP1C, PPARγ and C/EBPα
Fructus Gardeniae-induced gastrointestinal injury was associated with the inflammatory response mediated by the disturbance of vitamin B6, phenylalanine, arachidonic acid, taurine and hypotaurine metabolism
Stool-softening effect and action mechanism of free anthraquinones extracted from Rheum palmatum L. on water deficit-induced constipation in rats
Rhubarb granule promotes diethylnitrosamine-induced liver tumorigenesis by activating the oxidative branch of pentose phosphate pathway via G6PD in rats
The rhizomes of Atractylodes macrocephala Koidz improve gastrointestinal health and pregnancy outcomes in pregnant mice via modulating intestinal barrier and water-fluid metabolism
Bidirectional effects and mechanisms of traditional Chinese medicine
Research progress in the treatment of slow transit constipation by traditional Chinese medicine
Time-dependent laxative effect of sennoside A, the core functional component of rhubarb, is attributed to gut microbiota and aquaporins
Morning glory seed keeps laxative effect while retains less subchronic toxicity after being fried
| Unique citing works | 9 |
|---|---|
| Citations per year | 1,13 |
| Citation span | 2018 - 2024 (7) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 9 |