Integration of single-cell RNA sequencing and network pharmacology to elucidate the effect of Yantiao Formula on alleviating ALI by regulating the polarization of alveolar macrophages

Bibliographic Data

ID14733102
AuthorsDeng Liu (0000-0002-3765-648X, Shanghai University of Traditional Chinese Medicine), Yifei Zhang (0000-0002-9168-9231, Shanghai University of Traditional Chinese Medicine), Bufan Bai (Shanghai University of Traditional Chinese Medicine), Xudong Xiong (Shanghai University of Traditional Chinese Medicine, corresponding author), Qianmei Zhou (0000-0002-0275-9999, Shanghai University of Traditional Chinese Medicine, corresponding author), Rong Shi (0000-0002-5152-3026, Shanghai University of Traditional Chinese Medicine, corresponding author)
Year2025
Volume343
Pages119436
Publication date2025-03-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2025.119436
PMID39914692
OpenAlexW4407121854
LanguageEN
Citations received1
References cited31

YTF reduced the release of inflammatory factors and attenuated sepsis-induced ALI. The combined application of scRNA-seq, network pharmacology and molecular docking was helpful for revealing the mechanism of YTF, which was related to altering levels of M1 and M2 biomarkers to regulate macrophage polarization. The role of YTF in exerting its effects was closely relevant to the potential binding targets of its absorbed prototypes

Acute respiratory distress · ARDS · Biology · Gene · Gene expression · In vivo · KEGG · Lung · Sepsis · Transcriptome · Chemistry · Immune cells in cancer · Inflammation biomarkers and pathways · Medicine · Neuroinflammation and Neurodegeneration Mechanisms · Biochemistry · Genetics · Immunology · Internal Medicine · Pharmacology

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