Exploring the mechanism of Jianpi Huatan recipe in protecting hepatocellular carcinoma based on network pharmacology

Bibliographic Data

ID14733148
AuthorsCaiyun Zhang (0000-0002-9570-0207, Shanghai University of Traditional Chinese Medicine), Hongjiao Xiang (Shanghai University of Traditional Chinese Medicine), Junmin Wang (0000-0002-0930-5543, Shanghai University of Traditional Chinese Medicine), Gaoxuan Shao (0000-0001-6741-8354, Shanghai University of Traditional Chinese Medicine), Peilun Ding (Shanghai University of Traditional Chinese Medicine), Ying Gao (0000-0002-6793-9667, Shanghai University of Traditional Chinese Medicine), Hanchen Xu (0000-0003-0441-7500, Shanghai University of Traditional Chinese Medicine), Guang Ji (0000-0003-0842-3676, Shanghai University of Traditional Chinese Medicine, corresponding author), Tao Wu (0000-0002-0133-6783, Shanghai University of Traditional Chinese Medicine, corresponding author)
Year2023
Volume317
Pages116676
Publication date2023-12-01
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2023.116676
PMID37279814
OpenAlexW4379285008
LanguageEN
References cited26

Through network pharmacology and rat experiments, it is preliminarily confirmed that JPHTR may delay the progression of HCC by regulating the expression of Il-6/Jak2/Foxo3 in FOXO signal pathway, which is expected to be a new therapeutic target for the protection of HCC

Bioinformatics · Biology · Computational biology · Downregulation and upregulation · Drug · FOXO3 · Gene · Gene expression · Gene ontology · Gene regulatory network · Hepatocellular carcinoma · KEGG · Mechanism (biology · Systems pharmacology · Traditional Chinese medicine · Ferroptosis and cancer prognosis · FOXO transcription factor regulation · Genomics, phytochemicals, and oxidative stress · Medicine · Cancer Research · Genetics · Pharmacology

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