Saffron improves the efficacy of immunotherapy for colorectal cancer through the IL-17 signaling pathway

Bibliographic Data

ID14733191
AuthorsSiqi Feng (0009-0003-5313-5806, Shanghai University of Traditional Chinese Medicine), Shiying Li (0000-0002-8184-4568, Seoul National University), Zhonghua Wu (0000-0001-6252-3331), Zhong-Hua Wu (Shanghai University of Traditional Chinese Medicine), Yun Li (0000-0001-8225-4554, Shanghai University of Traditional Chinese Medicine), Tingting Wu (0000-0001-8236-2256, Shanghai University of Traditional Chinese Medicine), Zhangjie Zhou (Shanghai University of Traditional Chinese Medicine), Xinhua Liu (0000-0002-7797-6699, Shanghai University of Traditional Chinese Medicine), Jian Chen (0000-0002-9033-4033, Shanghai University of Traditional Chinese Medicine), Shujuan Fu (Shanghai University of Traditional Chinese Medicine), Zhiying Wang (0000-0003-3339-3085, Shanghai University of Traditional Chinese Medicine), Zhixian Zhong (0000-0002-5408-7776, Tongji University), Yi Zhong (0000-0002-1411-2711, Shanghai University of Traditional Chinese Medicine, corresponding author)
Year2025
Volume337
IssuePt 2
Pages118854
Publication date2025-01-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2024.118854
PMID39326815
OpenAlexW4402787885
LanguageEN
References cited43

The active components of saffron can reduce the expression of inflammatory factors and ameliorate the immunological microenvironment of tumors via the IL-17 signaling pathway, thereby improving the efficacy of immunotherapy for colorectal cancer. This study provides pharmacological support for the application of saffron in enhancing the efficacy of immunotherapy for colorectal cancer

Biological activity · Biology · Cancer · Cancer Immunotherapy · Colorectal cancer · Immunotherapy · In vitro · Pharmacognosy · Signal transduction · Traditional medicine · Medicine · Nigella sativa pharmacological applications · Phytochemistry and biological activity of medicinal plants · Saffron Plant Research Studies · Immunology · Internal Medicine · Oncology · Pharmacology