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Elucidation of plasma protein binding, blood partitioning, permeability, CYP phenotyping and CYP inhibition studies of Withanone using validated UPLC method

An active constituent of neuroprotective herb Ashwagandha

Bibliographic Data

ID14733391
AuthorsSandeep Kumar Singh (0000-0003-0213-2093, Central Drug Research Institute), Guru R Valicherla (0000-0002-1180-2530, Central Drug Research Institute), Anil Kumar Bikkasani (National Institute of Pharmaceutical Education and Research (NIPER) - Ahmedabad), Srikanth H Cheruvu (Central Drug Research Institute), Zakir Hossain (0000-0003-4128-3097, Central Drug Research Institute), Isha Taneja (Central Drug Research Institute), Hafsa Ahmad (Central Drug Research Institute), Siva Rama Raju Kanumuri (0000-0002-6087-6587, Central Drug Research Institute), Kanumuri S R Raju, Neelam S Sangwan (0000-0002-7766-5428, Central Institute of Medicinal and Aromatic Plants), Shio Kumar Singh (0000-0002-0859-3707, Central Drug Research Institute), Anil Kumar Dwivedi (0000-0001-6158-8096, Central Drug Research Institute), Mohammad Wahajuddin, Muhammad Wahajuddin (0000-0003-3362-7558, Central Drug Research Institute), Jiaur R Gayen (0000-0001-7703-9307, Central Drug Research Institute, corresponding author)
Year2021
Volume270
Pages113819
Publication date2021-04-01
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2021.113819
PMID33460762
OpenAlexW3121669307
LanguageEN
References cited47

ADME · Biology · Chromatography · Cytochrome P450 · In vitro · Metabolism · Microsome · Pharmacokinetics · Withania somnifera · Chemistry · Computational Drug Discovery Methods · Medicinal Plants and Neuroprotection · Medicine · Phytochemicals and Medicinal Plants · Biochemistry · Pharmacology

  • Studies on immunomodulatory activity of Withania somnifera (Ashwagandha) extracts in experimental immune inflammation

    Open Access•Ramesh Agarwal, Sham Diwanay et al.•Journal of Ethnopharmacology•1999

  • Withania somnifera root extract improves catecholamines and physiological abnormalities seen in a Parkinson's disease model mouse

    Open Access•Srinivasagam RajaSankar, Thamilarasan Manivasagam et al.•Journal of Ethnopharmacology•2009

Highly citedNo

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