Integrated phytochemistry and network pharmacology analysis to reveal effective substances and mechanisms of Bushen Quhan Zhiwang decoction in the treatment of rheumatoid arthritis

Bibliographic Data

ID14733679
AuthorsLiubo Zhang (Beijing University of Chinese Medicine), Liu-Bo Zhang, Yan Yu (0000-0003-4031-252X, China-Japan Friendship Hospital), Yu Yan (0009-0009-6373-2368), Ru Ma (0009-0008-8908-5034, Xian Mental Health Center), Dongxu Li (0000-0002-2630-4286, Shenyang Pharmaceutical University), Dong-Xu Li, Wei-Feng Yin, Weifeng Yin (Beijing University of Chinese Medicine), Qing-Wen Tao, Qingwen Tao (0000-0002-9163-8426, China-Japan Friendship Hospital, corresponding author), Yuan Xu (0000-0002-2341-7971, China-Japan Friendship Hospital, corresponding author)
Year2024
Volume325
Pages117897
Publication date2024-05-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2024.117897
PMID38336180
OpenAlexW4391617129
LanguageEN
Citations received2
References cited38

This study revealed the key active components and metabolites of BQZD. BQZD exhibits bone-protective effects via TRAF6/p38/JNK MAPK pathway, which may be associated with 9 absorbed components and 1 metabolite

Active metabolite · Arthritis · Decoction · MAPK/ERK pathway · Metabolite · Osteoclast · p38 mitogen-activated protein kinases · Receptor · Rheumatoid arthritis · Signal transduction · Traditional medicine · Bone Metabolism and Diseases · Chemistry · Medicine · Natural product bioactivities and synthesis · Rheumatoid Arthritis Research and Therapies · Biochemistry · Internal Medicine · Pharmacology