YangXueQingNaoWan attenuated blood brain barrier disruption after thrombolysis with tissue plasminogen activator in ischemia stroke

Bibliographic Data

ID14733846
AuthorsShu-Qi Yao, Shuqi Yao (State Administration of Traditional Chinese Medicine of the People's Republic of China), Yang Ye (0000-0003-0710-1341), Ye Yang (0000-0003-2827-3572, Peking University Third Hospital), Quan Li (0000-0003-4734-7709, Peking University), Xiao-Yi Wang (0000-0003-2300-3549, State Administration of Traditional Chinese Medicine of the People's Republic of China), Li Yan (0000-0002-5258-8649, State Administration of Traditional Chinese Medicine of the People's Republic of China), Xin-Mei Huo, Xinmei Huo (Peking University), Chun-Shui Pan, Chun‐Shui Pan (Shanghai Innovative Research Center of Traditional Chinese Medicine), Yu Fu (0000-0002-7129-8719, Peking University Third Hospital), Yu Can Fu (0000-0002-9097-7477), Jian Liu (0000-0002-1447-0973, Peking University), Jing-Yan Han (0000-0002-2286-8076, Peking University, corresponding author)
Year2024
Volume318
IssuePt B
Pages117024
Publication date2024-01-01
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2023.117024
PMID37572928
OpenAlexW4385791966
LanguageEN
Citations received2
References cited35

YXQNW relieved BBB damage and attenuated cerebral microvascular exudation and CH after tPA thrombolysis. The effect of YXQNW on cerebral microvascular exudation was associated with the inhibition of the low-expression of junction proteins, especially AJs mediated by Rho GTPase-activating protein 21 (Arhgap21), while the effect on CH was associated with the inhibition of leukocyte adhesion, the release of MMP-9 derived from macrophage, and low-expression and degradation of collagen IV and laminin in the vascular basement membrane

Albumin · Anesthesia · Blood–brain barrier · Central nervous system · Cerebral blood flow · Evans Blue · Extravasation · Ischemia · Occludin · Pathology · Tight junction · Tissue plasminogen activator · Acute Ischemic Stroke Management · Barrier Structure and Function Studies · Chemistry · Medicine · Neurological Disease Mechanisms and Treatments · Biochemistry · Internal Medicine · Pharmacology

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