Extract of Silphium perfoliatum L. improve lipid accumulation in NAFLD mice by regulating AMPK/FXR signaling pathway

Bibliographic Data

ID14733946
AuthorsJiyu Xu (Qinghai University), Wenjing Jia (0000-0001-8938-9515, Qinghai Tibetan Hospital), Guoying Zhang (0000-0002-3577-3316, Qinghai University), Liying Liu (0000-0002-0637-7488, Qinghai Tibetan Hospital), Luya Wang (0009-0008-9157-534X, Qinghai Tibetan Hospital), Di Wu (0000-0002-1269-4260, Qinghai University), Jihong Tao (Qinghai Tibetan Hospital), Huilan Yue (0000-0003-4457-3233, Qinghai Tibetan Hospital), Dejun Zhang (0000-0001-9129-534X, Qinghai University, corresponding author), Xiaohui Zhao (0000-0001-6641-7990, Qinghai Tibetan Hospital, corresponding author)
Year2024
Volume327
Pages118054
Publication date2024-06-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2024.118054
PMID38484950
OpenAlexW4392767778
LanguageEN
Citations received3
References cited32

For the first time, it is clarified that the extract rich in chlorogenic acids and its analogues in Silphium perfoliatum L. have good therapeutic effects on non-alcoholic fatty liver disease. It is confirmed that cryptochlorogenic acid is the main active compound and has good potential for medicine

AMPK · Biology · Enzyme · Lipid metabolism · Protein kinase A · Signal transduction · Chemistry · Diet, Metabolism, and Disease · Liver Disease Diagnosis and Treatment · Natural Antidiabetic Agents Studies · Biochemistry · Pharmacology

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