Overlooked switch from transient sedation to sustained excitement in the Biphasic effects of Ephedra Herb extract administered orally to mice
Bibliographic Data
| ID | 14734009 |
|---|---|
| Authors | Xuedan Huang (0000-0003-1399-2013, Kitasato University), Sumiko Hyuga (0000-0001-7612-2870, Kitasato Institute Hospital, corresponding author), Yoshiaki Amakura (Matsuyama University), Masashi Hyuga (0000-0003-0467-083X, National Institute of Health Sciences), Nahoko Uchiyama (0009-0000-0977-2056, National Institute of Health Sciences), Takashi Hakamatsuka (Nihon Pharmaceutical University), Yukihiro Goda (0000-0001-5617-3670, National Institute of Health Sciences), Hiroshi Odaguchi (0000-0002-8863-1557, Kitasato Institute Hospital), Toshihiko Hanawa (Kitasato Institute Hospital), Yoshinori Kobayashi (0000-0003-1914-6811, Kitasato University) |
| Year | 2023 |
| Volume | 301 |
| Pages | 115827 |
| Publication date | 2023-01-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2022.115827 |
| PMID | 36240977 |
| OpenAlex | W4304183141 |
| Language | EN |
| References cited | 36 |
We discovered for the first time that EHE evokes diphasic action by switching from transient sedation to sustained excitement. The transient sedation was evoked by the Eph and Pse in the herbal extract via activation of the α2a adrenoceptor and the sustained excitement was caused by the Eph in the herbal extract
Anesthesia · Antidepressant · Behavioural despair test · Ephedrine · Herb · Hippocampus · Medicinal herbs · Open field · Pseudoephedrine · Sedation · Sedative · Traditional medicine · Chemical synthesis and alkaloids · Medicine · Pain Management and Placebo Effect · Pharmacology and Obesity Treatment · Internal Medicine · Pharmacology
| Citation velocity | historical |
|---|---|
| Highly cited | No |