Mechanism of Qizhen decoction-mediated maturation of DC cells to activate the IL-12/JAK2/STAT4 pathway to sensitise PD-1 inhibitors in the treatment of colorectal cancer

Bibliographic Data

ID14734259
AuthorsXianbin Kong (0000-0002-2274-3142, Tianjin University of Traditional Chinese Medicine), Qingbo Li (0000-0001-6174-8512, Tianjin University of Traditional Chinese Medicine), Dong Wang (0000-0001-9454-3126, Tianjin University of Traditional Chinese Medicine), Michael D Wang (0000-0002-8114-8730), Miao Wang (0000-0002-4102-8582, Tianjin University of Traditional Chinese Medicine), Fan Yang (0000-0003-2978-7102, Tianjin University of Traditional Chinese Medicine, corresponding author), Jingyan Meng (0009-0003-1194-4891, Tianjin University of Traditional Chinese Medicine, corresponding author)
Year2024
Volume320
Pages117399
Publication date2024-02-01
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2023.117399
PMID37956913
OpenAlexW4388591692
LanguageEN
Citations received3
References cited104

The mechanism of action of the QZD sensitizing PD-1 inhibitor is to promote the maturation of DC cells to release IL-12 and activate the JAK2/STAT4 pathway to induce effector T cell activation by increasing the abundance of Akkermansia

Akkermansia · Biology · Cancer · Colorectal cancer · Decoction · Immune system · Cancer Immunotherapy and Biomarkers · Immune Cell Function and Interaction · Immune cells in cancer · Medicine · Cancer Research · Immunology · Internal Medicine · Pharmacology

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