QiShenYiQi pills preserve endothelial barrier integrity to mitigate sepsis-induced acute lung injury by inhibiting ferroptosis

Bibliographic Data

ID14734283
AuthorsZhixi Li (0000-0002-1125-8707, Harbin Engineering University), Yongjing Yu (Harbin Engineering University), Yue Bu (Harbin Medical University), Chang Liu (0000-0002-1198-6990, Harbin Engineering University), Jiaqi Jin (0009-0000-0645-3818, Capital Medical University), Wenqiang Li (0000-0002-0833-246X, Jinshan Hospital of Fudan University), Guangmin Chen (0000-0001-9103-5193, Harbin Medical University), Enran Liu (Harbin Medical University), Yan Zhang (0000-0001-8460-2671, Harbin Medical University), Weidong Gong (Harbin Medical University), Juan Luo (0000-0002-1031-5263, Harbin Medical University), Ziyong Yue (Harbin Medical University, corresponding author)
Year2024
Volume322
Pages117610
Publication date2024-03-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2023.117610
PMID38122915
OpenAlexW4389941219
LanguageEN
Citations received2
References cited41

This study demonstrated that QSYQ maintains pulmonary vascular barrier integrity by inhibiting ferroptosis in CLP mice. These findings partially elucidate the mechanism of QSYQ in si-ALI and further clarify the active components of QSYQ, thereby providing a scientific theoretical basis for treating si-ALI with QSYQ

Bronchoalveolar lavage · Inflammation · Lung · Pathology · Sepsis · Traditional Chinese medicine · Western blot · Cancer-related molecular mechanisms research · Chemistry · Ferroptosis and cancer prognosis · Immune cells in cancer · Medicine · Immunology · Internal Medicine · Pharmacology

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