Sub-chronic realgar exposure causes liver inflammatory injury in mice by inducing bile acid-mediated NLRP3 inflammasome activation through down-regulation of ileal FXR
Bibliographic Data
| ID | 14734339 |
|---|---|
| Authors | Guangyan Li (0000-0003-2890-0556, China Medical University), T Wang (0009-0002-7365-5596, China Medical University), Yixuan Xie (0009-0005-9138-6635, China Medical University), Lu He (0000-0002-7367-2452, China Medical University), Huan Liu (0000-0001-8772-1545, China Medical University), Hongying Chen (0000-0001-8258-0683, China Medical University), Hong Jiang (0000-0002-9299-5484, China Medical University), Taoguang Huo (China Medical University, corresponding author) |
| Year | 2025 |
| Volume | 351 |
| Pages | 120174 |
| Publication date | 2025-07-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2025.120174 |
| PMID | 40541751 |
| OpenAlex | W4411403822 |
| Language | EN |
| References cited | 35 |
Bile acid · Enterohepatic circulation · Farnesoid X receptor · Inflammasome · Inflammation · Lipocalin · Liver injury · Nuclear receptor · Realgar · Traditional medicine · Western blot · Chemistry · Drug Transport and Resistance Mechanisms · Genomics, phytochemicals, and oxidative stress · Liver Disease Diagnosis and Treatment · Medicine · Biochemistry · Endocrinology · Internal Medicine · Pharmacology
Target RNA expression omics approach to reveal the liver detoxification effect induced by Chinese medicine prescription Niu Huang Jie Du against realgar overexposure to mice
Target lipidomics approach to reveal the resolution of inflammation induced by Chinese medicine combination in Liu-Shen-Wan against realgar overexposure to rats
HNMR-based metabonomic study of sub-chronic hepatotoxicity induced by realgar
Sub-chronic exposure to realgar induces liver injury via upregulating the TXNIP/NLRP3 pathway and disturbing bile acid homeostasis in mice
| Citation velocity | historical |
|---|---|
| Highly cited | No |