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Sub-chronic realgar exposure causes liver inflammatory injury in mice by inducing bile acid-mediated NLRP3 inflammasome activation through down-regulation of ileal FXR

Bibliographic Data

ID14734339
AuthorsGuangyan Li (0000-0003-2890-0556, China Medical University), T Wang (0009-0002-7365-5596, China Medical University), Yixuan Xie (0009-0005-9138-6635, China Medical University), Lu He (0000-0002-7367-2452, China Medical University), Huan Liu (0000-0001-8772-1545, China Medical University), Hongying Chen (0000-0001-8258-0683, China Medical University), Hong Jiang (0000-0002-9299-5484, China Medical University), Taoguang Huo (China Medical University, corresponding author)
Year2025
Volume351
Pages120174
Publication date2025-07-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2025.120174
PMID40541751
OpenAlexW4411403822
LanguageEN
References cited35

Bile acid · Enterohepatic circulation · Farnesoid X receptor · Inflammasome · Inflammation · Lipocalin · Liver injury · Nuclear receptor · Realgar · Traditional medicine · Western blot · Chemistry · Drug Transport and Resistance Mechanisms · Genomics, phytochemicals, and oxidative stress · Liver Disease Diagnosis and Treatment · Medicine · Biochemistry · Endocrinology · Internal Medicine · Pharmacology

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  • Target lipidomics approach to reveal the resolution of inflammation induced by Chinese medicine combination in Liu-Shen-Wan against realgar overexposure to rats

    Open Access•Jiaojiao Wang, Lanfang Ding et al.•Journal of Ethnopharmacology•2020

  • HNMR-based metabonomic study of sub-chronic hepatotoxicity induced by realgar

    Open Access•Taoguang Huo, Ying Fang et al.•Journal of Ethnopharmacology•2016

  • Sub-chronic exposure to realgar induces liver injury via upregulating the TXNIP/NLRP3 pathway and disturbing bile acid homeostasis in mice

    Open Access•Aihong Li, Xinyu Wu et al.•Journal of Ethnopharmacology•2021

Citation velocityhistorical
Highly citedNo

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