Guiqi Huoxue capsule alleviates cervical spondylosis in rats

Insights from 16S rRNA sequencing, lipidomics, and network pharmacology

Bibliographic Data

ID14735650
AuthorsHongguang Tang (Ocean University of China), Wenting Ni (Shandong University of Traditional Chinese Medicine), Dejun Niu (Luye Pharma (China)), Kun Wang (0000-0002-6199-4315, Shandong University of Traditional Chinese Medicine), Mengmeng Shen (0000-0003-2631-5126, Luye Pharma (China)), Fanqiang Meng (0009-0005-4768-4416, Luye Pharma (China)), Deyu Cui (Ocean University of China), Zhen Zeng (0000-0001-8481-3567, Luye Pharma (China)), Chenghong Sun (0000-0002-7579-5472, Luye Pharma (China)), Jinyang Shen (0000-0002-0469-181X, Ocean University of China, corresponding author), Shirong Li (0009-0008-3509-8585, Luye Pharma (China), corresponding author), Yue Zhou (0009-0009-2070-9715, Lianyungang Oriental Hospital, corresponding author)
Year2025
Volume347
Pages119752
Publication date2025-05-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2025.119752
PMID40194639
OpenAlexW4409203454
LanguageEN
References cited43

This study elucidated the role of GQHX in alleviating CS and highlighted the mechanisms involved, particularly the regulation of gut microbiota and lipid metabolism, as well as the AGE-RAGE, MAPK, and HIF-1 signaling pathways

Alternative medicine · Bioinformatics · Biology · Capsule · Cervical spondylosis · Lipidomics · Pathology · Traditional medicine · Healthcare and Venom Research · Medicine · Pharmacological Effects of Natural Compounds · Traditional Chinese Medicine Studies · Pharmacology

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