Exploring the potential active components and mechanisms of Tetrastigma hemsleyanum against ulcerative colitis based on network pharmacology in LPS-induced RAW264.7 cells

Bibliographic Data

ID14735899
AuthorsQiang Zhang (0000-0003-4613-3100, corresponding author), Tinghui Feng (Northwest A&F University), Qinxiang Chang (0009-0007-7472-2734), Dongfeng Yang (0000-0002-0505-3916), Yuan Li (0000-0001-7139-4391), Yujie Shang, Wenxin Gao (0009-0000-5652-7969), Jiayan Zhao (0000-0002-8533-6042), Xiaohu Li (0000-0003-0888-8756, Shaanxi University of Chinese Medicine), Lei Ma (0000-0003-4268-0596), Zongsuo Liang (0000-0001-7336-7741)
Year2025
Volume342
Pages119384
Publication date2025-02-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2025.119384
PMID39863095
OpenAlexW4406757363
LanguageEN
Citations received2
References cited90

The results demonstrate that TH_E and isorhamnetin alleviate LPS-induced UC through restraining ferroptosis. Moreover, isorhamnetin's anti-UC properties are mediated by inhibiting ferroptosis via activation of the Keap1/Nrf2/HO-1 axis

Biological activity · Colitis · Disease · In vitro · Pathology · Pharmacognosy · Traditional medicine · Ulcerative colitis · Chemistry · Computational Drug Discovery Methods · Medicine · Natural product bioactivities and synthesis · Pharmacological Effects of Natural Compounds · Biochemistry · Immunology · Pharmacology

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Open DOIOpen Access