Presence of aromatase inhibitors in cycads
Bibliographic Data
| ID | 14735904 |
|---|---|
| Authors | Maria T Kowalska (Fairchild Tropical Botanic Garden), Yossef Itzhak (University of Miami), David Puett (University of Georgia, corresponding author) |
| Year | 1995 |
| Volume | 47 |
| Issue | 3 |
| Pages | 113-116 |
| Publication date | 1995-07-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/0378-8741(95)01259-g |
| PMID | 8569233 |
| OpenAlex | W2039284237 |
| Language | EN |
| References cited | 9 |
Cycads, the most primitive of the living gymnosperms, have been used and continue to be used for food and medicinal purposes by many cultures, although toxins must be removed before ingestion. In our quest to identify tropical plants that contain inhibitors of the cytochrome P-450 aromatase and thus may be efficacious in treating estrogen-dependent tumors, we have screened extracts from 5 species of cycad folia encompassing 3 genera: Cycas cairnsiana F. Muell., Cycas revoluta Thunb., Cycas rumphii Miq., Dioon spinulosum Dyer and Encephalartos ferox Bertol. All extracts were found to contain inhibitors of the human enzyme
Aromatase · Biological activity · Biology · Botany · Cancer · Cycad · Pharmacognosy · Traditional medicine · Botany and Geology in Latin America and Caribbean · Medicine · Biochemistry · Genetics
| Citation velocity | historical |
|---|---|
| Highly cited | No |