Ilex cornuta leaves extracts ameliorate hyperuricemia by modulating uric acid transporters
Bibliographic Data
| ID | 14736104 |
|---|---|
| Authors | Yucheng Mao (0009-0007-7124-4431, Zhejiang Sci-Tech University), Hongliang Xu (0009-0001-6114-7925), Xu Hongliang (Tasly Holding Group (China)), Pengguo Xia (0000-0003-3572-7616, Zhejiang Sci-Tech University, corresponding author) |
| Year | 2025 |
| Volume | 336 |
| Pages | 118618 |
| Publication date | 2025-01-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2024.118618 |
| PMID | 39069031 |
| OpenAlex | W4401009092 |
| Language | EN |
| Citations received | 3 |
| References cited | 30 |
The crude flavonoids and saponins of Ilex cornuta leaves not only inhibited XOD activity in vitro, but also significantly controlled XOD activity and reduced UA level in hyperuricemia mice in vivo. One of the potential mechanisms was to regulate UA level in vivo by regulating ABCG2, GLUT9, and URAT1 transporters directly related to UA transport, thus achieving the effect of intervening hyperuricemia. This study provided a preliminary experimental basis for the development of new drugs of Ilex cornuta leaves for treating hyperuricemia
Biological activity · Biology · Gene · Hyperuricemia · In vitro · Pharmacognosy · Traditional medicine · Transporter · Uric acid · Gout, Hyperuricemia, Uric Acid · Medicine · Pharmacological Effects of Natural Compounds · Therapeutic Uses of Natural Elements · Biochemistry · Pharmacology
| Unique citing works | 3 |
|---|---|
| Citations per year | 3 |
| Citation span | 2025 - 2026 (2) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 3 |