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Safety, tolerability, pharmacokinetics, and food effect of baicalein tablets in healthy Chinese subjects

A single-center, randomized, double-blind, placebo-controlled, single-dose phase I study

Bibliographic Data

ID14736220
AuthorsRuihua Dong (0000-0003-3382-9547, Academy of Military Medical Sciences), Lijun Li (0009-0007-0818-6929, Capital Medical University), Hongzhi Gao (0000-0002-5821-2407, Academy of Military Medical Sciences), Kun Lou (Shijiazhuang Yiling Pharmaceutical (China)), Hongmei Luo (0000-0001-8130-8565), Sheng Hao (0009-0002-9189-6609, Shijiazhuang Yiling Pharmaceutical (China)), Jing Yuan (0000-0002-4262-4116, Shijiazhuang Yiling Pharmaceutical (China)), Zeyuan Liu (0000-0003-3862-6079), Liu Ze-yuan (0000-0003-2663-7440, Academy of Military Medical Sciences, corresponding author)
Year2021
Volume274
Pages114052
Publication date2021-06-01
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2021.114052
PMID33753147
OpenAlexW3139271702
LanguageEN
Citations received2
References cited18

Adverse effect · Baicalein · Pharmacokinetics · Placebo · Scutellaria baicalensis · Tolerability · Traditional Chinese medicine · Traditional medicine · Flavonoids in Medical Research · Medicine · Natural product bioactivities and synthesis · Phytochemistry and Biological Activities · Pharmacology

  • Short-Chain Fatty Acid Metabolism in Acute Lung Injury and Intervention Strategies from Traditional Chinese Medicine

    Open Access•Bing Zhao, Rongrong Li et al.•Journal of Ethnopharmacology•2026

  • Identification and high-throughput quantification of baicalein and its metabolites in plasma and urine

    Open Access•Hao Wang, Yantong Sun et al.•Journal of Ethnopharmacology•2023

  • Anti-H1N1 virus, cytotoxic and Nrf2 activation activities of chemical constituents from Scutellaria baicalensis

    Open Access•Shuai Ji, Ru Li et al.•Journal of Ethnopharmacology•2015

  • Safety, tolerability, and pharmacokinetics of a single ascending dose of baicalein chewable tablets in healthy subjects

    Open Access•Min Li, Aixin Shi et al.•Journal of Ethnopharmacology•2014

Citations per year0.67
Citation span2023 - 2026 (4)
Highly citedNo

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