Buyang Huanwu decoction promotes post-stroke white matter repair via TREM2-Dependent microglial phagocytosis and IGF1 secretion

Xiaoli Qin; Yunsha Zhang; Jiaxu Liu; Guangxu Xiao; Yuying Guo; Hao Deng; Hongying Hao; Wenzhe Xu; Xueqi Cheng; Linna Zhao; Shixin Xu

doi:10.1016/j.jep.2025.120520

Buyang Huanwu decoction promotes post-stroke white matter repair via TREM2-Dependent microglial phagocytosis and IGF1 secretion

Bibliographic Data

ID	14736685
Authors	Xiaoli Qin (0000-0003-2532-9841, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine), Yunsha Zhang (0000-0003-3722-6524, Tianjin University of Traditional Chinese Medicine), Jun Liu (0000-0001-5393-3187, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine), Jiaxu Liu (0000-0003-0815-3979, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine), Guangxu Xiao (0000-0003-3996-6622, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine), Yuying Guo (0000-0002-2339-9742, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine), Hao Deng (0000-0002-7714-629X, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine), Hongying Hao (0000-0002-6035-8771, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine), Wenzhe Xu (0000-0002-4063-1961, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine), Xueqi Cheng (0000-0002-5201-8195, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine), Linna Zhao (0000-0003-3918-6722, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine), Shixin Xu (0000-0003-2270-2911, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine)
Year	2026
Volume	355
Issue	Pt A
Pages	120520
Publication date	2026-01-01
Peer Reviewed	Yes
Open Access	Yes
Type	ARTICLE
Venue	Journal of Ethnopharmacology (JOURNAL)
Journal identifiers	ISSN: 0378-8741 • E-ISSN: 1872-7573
Publisher	Elsevier BV (PUBLISHER)
DOI	10.1016/j.jep.2025.120520
PMID	40912481
OpenAlex	W4414001893
Language	EN
References cited	67

Biological activity · Biology · Decoction · In vitro · Inflammation · Microglia · Phagocytosis · Pharmacognosy · Secretion · Stroke (engine · Traditional medicine · TREM2 · Biochemistry · Endocrinology · Engineering · Immunology · Inflammation biomarkers and pathways · Medicine · Neuroinflammation and Neurodegeneration Mechanisms · Neurological Disease Mechanisms and Treatments · Pharmacology

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Open DOI

Citation velocity	historical
Highly cited	No

Buyang Huanwu decoction promotes post-stroke white matter repair via TREM2-Dependent microglial phagocytosis and IGF1 secretion

Bibliographic Data

Buyang Huanwu decoction alleviates oxidative injury of cerebral ischemia-reperfusion through PKCε/Nrf2 signaling pathway

Buyang Huanwu Decoction promotes neurovascular remodeling by modulating astrocyte and microglia polarization in ischemic stroke rats

Buyang huanwu decoction alleviates stroke-induced immunosuppression in MCAO mice by reducing splenic T cell apoptosis triggered by AIM2 inflammasome

Astragaloside IV promotes cerebral tissue restoration through activating AMPK- mediated microglia polarization in ischemic stroke rats

Buyang Huanwu decoction improves motor function by enhancing internal capsule reorganization through inhibiting Notch signaling after ischemic stroke

Buyang huanwu decoction promotes remyelination via miR-760-3p/GPR17 axis after intracerebral hemorrhage

Glycosides of Buyang Huanwu decoction inhibits inflammation associated with cerebral ischemia-reperfusion via the Pink1/Parkin mitophagy pathway

Buyang Huanwu decoction promotes gray and white matter remyelination by inhibiting Notch signaling activation in the astrocyte and microglia after ischemic stroke

IGF-1 signaling pathway activation promotes axonal regeneration and repair

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