Quercetin inhibits mesothelial-mesenchymal transition and alleviates postoperative peritoneal adhesions by blocking the TGF-β1/PI3K/AKT pathway

Bibliographic Data

ID14736733
AuthorsGan Li (0000-0002-4237-7119, First Affiliated Hospital of Xi'an Jiaotong University), Yiwei Ren (0000-0002-6121-3486, First Affiliated Hospital of Xi'an Jiaotong University), Enmeng Li (0000-0002-7801-0116, First Affiliated Hospital of Xi'an Jiaotong University), Kai Deng (0000-0002-9274-7894, First Affiliated Hospital of Xi'an Jiaotong University), Chao Qu (0000-0002-6313-5688, First Affiliated Hospital of Xi'an Jiaotong University), Junxiang Zhang (0009-0003-2561-7656, First Affiliated Hospital of Xi'an Jiaotong University), Li Zhang (0000-0002-4441-5131, First Affiliated Hospital of Xi'an Jiaotong University), Xingjie Wang (0000-0002-8277-8021, First Affiliated Hospital of Xi'an Jiaotong University), J I Lian (0009-0006-5935-0592), Jie Lian (0000-0003-2351-2570, First Affiliated Hospital of Xi'an Jiaotong University), Huayou Zhou (0000-0002-7447-8918, First Affiliated Hospital of Xi'an Jiaotong University), Zijun Wang (0000-0002-2095-2151, First Affiliated Hospital of Xi'an Jiaotong University), Tianli Shen (0000-0001-8922-1229, First Affiliated Hospital of Xi'an Jiaotong University), Xuqi Li (0000-0002-2497-020X, First Affiliated Hospital of Xi'an Jiaotong University, corresponding author), Zhengdong Jiang (0000-0003-0234-5478, First Affiliated Hospital of Xi'an Jiaotong University, corresponding author)
Year2024
Volume319
IssuePt 2
Pages117242
Publication date2024-01-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2023.117242
PMID37777024
OpenAlexW4387122314
LanguageEN
References cited35

QUE can not only reduce postoperative TGF-β1 but also block the TGF-β1/PI3K/AKT pathway to inhibit MMT of mesothelial cells, and finally alleviate postoperative peritoneal adhesions. These findings may provide insights towards development of a safe and effective anti-adhesive drug for prevention of postoperative peritoneal adhesions

Biology · Carthamus · Flos · PI3K/AKT/mTOR pathway · Quercetin · Signal transduction · Traditional medicine · Western blot · Endometriosis Research and Treatment · Hernia repair and management · Intestinal and Peritoneal Adhesions · Medicine · Biochemistry · Cell Biology · Pharmacology

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