Zhichuanling oral liquid attenuates airway inflammation in asthma by targeting the STIM1/CHOP/JNK axis

Bibliographic Data

ID14737202
AuthorsHuidan Chen (0009-0003-3839-7904, Changchun University of Chinese Medicine), Sihui Xing (Changchun University of Chinese Medicine), Shijie Xing (0000-0001-9733-3407, Changchun University of Chinese Medicine), Jiaqi Wu (0000-0003-2785-5677, Foshan Maternity and Child Health Care Hospital), Yue Li (0009-0004-9365-9070, Changchun Institute of Optics, Fine Mechanics and Physics), Yang Xia (0000-0002-3169-6966, Yanbian University), Xia Yang (0000-0002-8142-5857, Yanbian University), Zhongtian Wang (0000-0003-3417-9865, Changchun University of Chinese Medicine), Jinpu Zhu (0009-0005-8513-2073, Changchun University of Chinese Medicine), Siye Lv, Shkarenkova Lv (Changchun University of Chinese Medicine), Shengmei Xu (Guangzhou University of Chinese Medicine), Shangge Xu (Guangzhou University of Chinese Medicine), Yilong Zhu (0000-0003-3924-9324, Changchun University of Chinese Medicine, corresponding author), Liping Sun (0000-0003-3637-0305, Changchun University of Chinese Medicine, corresponding author)
Year2026
Volume356
Pages120859
Publication date2026-02-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2025.120859
PMID41197928
OpenAlexW4415880081
LanguageEN
References cited61

ZCLOL alleviates airway inflammation and hyperresponsiveness in asthma by restoring Ca 2+ homeostasis and suppressing ERS through inhibition of the STIM1/CHOP/JNK axis. These findings provide mechanistic evidence supporting ZCLOL as a potential multi-target therapeutic strategy for asthma

Airway · Airway hyperresponsiveness · Asthma · Bronchial hyperresponsiveness · Homeostasis · Inflammation · Inflammasome and immune disorders · Inhalation and Respiratory Drug Delivery · Ion Channels and Receptors

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