Huangqin tang alleviates colitis-associated colorectal cancer via amino acids homeostasisand PI3K/AKT/mtor pathway modulation

Bibliographic Data

ID14737447
AuthorsDunfang Wang (Chinese Academy of Medical Sciences & Peking Union Medical College), Lin Zhu (0000-0001-5298-7431, Chinese Academy of Medical Sciences & Peking Union Medical College), Zhu Lin (0000-0003-3612-6177), Haifan Liu (Chinese Academy of Medical Sciences & Peking Union Medical College), Xue Feng (0000-0003-0845-8000, Chinese Academy of Medical Sciences & Peking Union Medical College), Caijuan Zhang (Chinese Academy of Medical Sciences & Peking Union Medical College), Tao Li (0000-0001-7895-4136, Chinese Academy of Medical Sciences & Peking Union Medical College), Bin Liu (0000-0002-7467-2331, Chinese Academy of Medical Sciences & Peking Union Medical College), Li Liu (0000-0002-5257-3391, Chinese Academy of Medical Sciences & Peking Union Medical College), Jingwei Sun (0000-0002-6204-5584, Beijing University of Chinese Medicine), Hao Chang (0000-0003-3778-2328), Hao-Hsiang Chang (0000-0001-5836-0728, Chinese Academy of Medical Sciences & Peking Union Medical College), Siyuan Chen (0000-0002-3118-5963, Chinese Academy of Medical Sciences & Peking Union Medical College), Shanshan Guo (0000-0001-9258-5728, Chinese Academy of Medical Sciences & Peking Union Medical College, corresponding author), Weipeng Yang (0000-0002-8057-2863, Chinese Academy of Medical Sciences & Peking Union Medical College, corresponding author)
Year2024
Volume334
Pages118597
Publication date2024-11-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2024.118597
PMID39034016
OpenAlexW4400859764
LanguageEN
Citations received2
References cited70

HQT is effective in alleviating and delaying the colon "inflammation-to-cancer". The mechanism of action may involve HQT maintained AAs metabolism homeostasis and regulated PI3K/AKT/mTOR pathway, so as to maintain the balance between proliferation and apoptosis, and then interfere in the occurrence and development of CAC

Alternative medicine · Cancer · Colitis · Colorectal cancer · Mechanism (biology · Pathology · PI3K/AKT/mTOR pathway · Signal transduction · Traditional Chinese medicine · Cancer Mechanisms and Therapy · Chemistry · Genomics, phytochemicals, and oxidative stress · Medicine · Pharmacological Effects of Natural Compounds · Biochemistry · Internal Medicine · Pharmacology

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