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Harnessing the potential of medicinal plants in the malaria fighting

In vitro and in vivo antiplasmodial activities of Feretia apodanthera Delille (Rubiaceae)

Bibliographic Data

ID14738231
AuthorsSaamou Isaac Boni (0009-0004-4107-1814, Centre National de la Recherche Scientifique, corresponding author), Domonbabele François De Sales Hien (0000-0002-8136-2702, Institut de Recherche en Sciences de la Santé), Kouliga Benjamin Koama (Nazi Boni University), Mariam Youba (Institut de Recherche en Sciences de la Santé), Virginie Vaissayre (Centre National de la Recherche Scientifique), Zachari Kabre (Nazi Boni University), Stéphane Dussert (0000-0001-5222-4282, Centre National de la Recherche Scientifique), Abdoulaye Diabate (Institut de Recherche en Sciences de la Santé), Thierry Lefèvre (0000-0002-9736-6142, Centre National de la Recherche Scientifique), Rakiswendé Serge Yerbanga (0000-0001-8345-0880, Nazi Boni University), Mohamed Haddad (0000-0001-6631-190X), Haddad Mohamed (0000-0001-5599-9980, Université Toulouse III - Paul Sabatier), Nâg-Têro Roland Meda (Nazi Boni University), Nâg-Tiero Roland Meda (Nazi Boni University)
Year2026
Volume355
IssuePt B
Pages120729
Publication date2026-01-01
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2025.120729
PMID41076146
OpenAlexW4414978124
LanguageEN
References cited60

Overall, all three organs of F. apodanthera exhibited antiplasmodial activity both in vitro and in vivo while remaining non-toxic. The leaf demonstrated superior chemosuppressive and schizonticidal activity, along with strong trophozoitocidal effects, whereas the root and stem bark excelled in trophozoitocidal activity. These findings support the traditional use of F. apodanthera in malaria treatment and highlight its potential for developing antimalarial phytomedicines

Bark (sound · In vitro · In vivo · Malaria · Medicinal plants · Pharmacognosy · Bioactive natural compounds · Ethnobotanical and Medicinal Plants Studies · Malaria Research and Control · Traditional and Medicinal Uses of Annonaceae

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