Jiedu Huayu suppress ferroptosis induced by 5-lipoxygenase-dependent peroxidation in acute liver failure

Bibliographic Data

ID14738286
AuthorsYong Lin (0000-0002-5710-5036, Guangxi University of Chinese Medicine), Yong Du (0000-0003-1864-8326, Guangxi University of Chinese Medicine), Yuanqi Du (0000-0003-2988-0374), Minggang Wang (0000-0002-0572-7204, The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine), Jiongfen Li, Jin‐Long Li (0000-0002-5133-9165, Guangxi University of Chinese Medicine), H Li (0000-0002-7931-9895, Guangxi University of Chinese Medicine), De Wang (0000-0002-0651-709X, Guangxi University of Chinese Medicine), David Pang (0000-0002-9524-3130, The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine), Di Pang (0009-0009-5969-0775), Na Wang (0000-0003-1102-8220, The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine), Dewen Mao (0000-0001-9438-9325, The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, corresponding author), Fuli Long (0000-0003-1196-2697, The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, corresponding author)
Year2025
Volume353
IssuePt A
Pages120343
Publication date2025-09-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2025.120343
PMID40754030
OpenAlexW4412862406
LanguageEN
References cited36

JDHY suppresses 5-LOX-catalyzed lipid peroxidation via negative feedback regulation of the cAMP-PKA pathway, mitigating ALF-associated ferroptosis. Moreover, the data provided in this paper suggest that 5-LOX can serve as a potential target for inhibiting ALF ferroptosis, providing a scientific basis for the clinical prevention and treatment of ALF

Antioxidant · Arachidonate 5-lipoxygenase · Arachidonic acid · Enzyme · Lipid peroxidation · Lipoxygenase · Liver failure · Cancer-related molecular mechanisms research · Chemistry · Circular RNAs in diseases · Ferroptosis and cancer prognosis · Medicine · Biochemistry · Internal Medicine · Pharmacology

Tools

Open DOIOpen Access