Chemical and in vitro toxicity analysis of a supercritical fluid extract of Kava kava (Piper methysticum)
Bibliographic Data
| ID | 14738867 |
|---|---|
| Authors | Greg E Petersen (Cellular Engineering Technologies (United States), corresponding author), Yijin Tang (Cellular Engineering Technologies (United States)), Christine Fields (Crossref) |
| Year | 2019 |
| Volume | 235 |
| Pages | 301-308 |
| Publication date | 2019-05-01 |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2019.01.032 |
| PMID | 30710733 |
| OpenAlex | W2914648455 |
| Language | EN |
| References cited | 45 |
KAVOATM, a supercritical carbon dioxide extract of kava displays a similar kavalactone profile to a noble variety of kava. In relation to total kavalactone content, KAVOATM also has a lower content of the cytotoxic compound FKB. Aqueous extractions of KAVOATM and noble kava root had no significant negative impact on cell viability and toxicity on HepG2 cells when compared to vehicle controlled treated cells. Results indicate KAVOATM demonstrates a similar in vitro safety profile to that of noble kava root when experiments are normalized to kavalactone content
Chromatography · Extraction (chemistry · In vitro · Kava · Supercritical fluid extraction · Toxicity · Traditional medicine · Viability assay · Alkaloids: synthesis and pharmacology · Chemistry · Medicinal Plant Extracts Effects · Medicine · Nephrotoxicity and Medicinal Plants · Biochemistry
| Highly cited | No |
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