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Mouse neuronal dendritic complexity and resilience to stress-induced depression in Drosophila melanogaster are enhanced by Withania somnifera alkaloids

Bibliographic Data

ID14738886
AuthorsR Dutta (0000-0002-6095-7627, Oregon State University, corresponding author), Helen Holvoet (Johannes Gutenberg University Mainz), Luke Marney (0000-0001-8117-8246, Oregon State University), Kadine Cabey (Oregon Health & Science University), Cody Neff, Cody J Neff (Oregon Health & Science University), Mikah Brandes, Mikah S Brandes (0000-0003-0892-1608, Oregon Health & Science University), Jonathan Zweig, Jonathan A Zweig (0000-0002-7015-9821, Oregon Health & Science University), Jesús Martínez (0000-0002-5611-3763), Jesús Miñano Martínez (Oregon Health & Science University), Jaewoo Choi (0000-0001-6376-3089, Oregon State University), Christine McClure (0000-0003-3865-9022, Oregon Health & Science University), Md Nure Alam (0000-0001-7579-2346, Oregon State University), Liping Yang (0000-0002-2606-6740, Oregon State University), Burkhard Poeck (Johannes Gutenberg University Mainz), Jan F Stevens (0000-0002-6348-9347, Oregon State University), Doris Kretzschmar (0000-0002-0519-2377, Oregon Health & Science University), Nora E Gray (0000-0001-6848-859X, Oregon Health & Science University), Roland Strauss (Johannes Gutenberg University Mainz), Claudia S Maier (0000-0003-0743-8956, Oregon State University), Amala Soumyanath (0000-0003-1569-6453, Oregon Health & Science University, corresponding author)
Year2026
Volume357
Pages120905
Publication date2026-02-01
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2025.120905
PMID41275942
OpenAlexW4416528203
LanguageEN
References cited70

These findings highlight a role for alkaloids, including acetyltropine, as potential active constituents of WS associated with neuroprotective and anti-stress effects traditionally attributed to this plant. Results support continued evaluation of additional WS active compounds beyond withanolides

Depression (economics · Drosophila melanogaster · Melanogaster · Neuroprotection · Pharmacognosy · Resilience (materials science · Withania somnifera · Medicinal Plants and Neuroprotection · Memory and Neural Mechanisms · Phytochemicals and Medicinal Plants

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