Narcissoside from Bupleurum chinense DC. Alleviates depression by enhancing adult hippocampal neurogenesis via the TREM2/PI3K/Akt pathway
Bibliographic Data
| ID | 14739291 |
|---|---|
| Authors | Ruonan Shuang (Chengdu University of Traditional Chinese Medicine), Yue Tong (0009-0003-6881-2080, Chengdu University of Traditional Chinese Medicine), Xinge Wang (0000-0003-0028-8510, Chengdu University of Traditional Chinese Medicine), Dahai Hou (0009-0001-8456-4334, Nanjing University of Chinese Medicine), Huina Yang, Hyun Suk Yang (0000-0002-7056-3648, Nanjing University of Chinese Medicine), Shijun Xu (0000-0002-5334-7871, Chengdu University of Traditional Chinese Medicine, corresponding author), Chang Chen (0000-0003-4937-8103, Nanjing University of Chinese Medicine, corresponding author) |
| Year | 2025 |
| Volume | 353 |
| Issue | Pt A |
| Pages | 120323 |
| Publication date | 2025-09-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2025.120323 |
| PMID | 40716620 |
| OpenAlex | W4412725367 |
| Language | EN |
| References cited | 68 |
Antidepressant · Behavioural despair test · Biology · Hippocampus · Inflammation · Neurogenesis · Neuroinflammation · Neuroprotection · Open field · PI3K/AKT/mTOR pathway · Protein kinase B · Signal transduction · Tail suspension test · Chemistry · Medicine · Neurogenesis and neuroplasticity mechanisms · Neuroinflammation and Neurodegeneration Mechanisms · Neuroscience · Tryptophan and brain disorders · Biochemistry · Internal Medicine · Pharmacology
Socio-economic variations in the mental health treatment gap for people with anxiety, mood, and substance use disorders
Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder
Understanding the somatic consequences of depression
Bupleurum chinense DC improves Cums-induced depressive symptoms in rats through upregulation of the cAMP/PKA/CREB signalling pathway
Saikosaponin B2 ameliorates depression-induced microglia activation by inhibiting ferroptosis-mediated neuroinflammation and ER stress
Saikosaponin a activates tet1/dll3/notch1 signalling and promotes hippocampal neurogenesis to improve depression-like behavior in mice
| Citation velocity | historical |
|---|---|
| Highly cited | No |