Hedyotis diffusa Willd. extract alleviates CCl4-induced liver fibrosis via modulation of the gut microbiota and FXR/SHP/CYP7A1-mediated bile acid metabolism
Bibliographic Data
| ID | 14739751 |
|---|---|
| Authors | Cheng Wang (0000-0002-4693-6424, Chengdu Medical College, corresponding author), Min Luo (0000-0001-9062-8931, Chengdu Medical College), Qixiang Chen (0000-0002-7646-6216, Chengdu Medical College), Lingli Zheng (Chengdu Medical College), Ting Jiang (0000-0002-2276-9174, Chengdu Medical College), Min Dai (0000-0002-8270-9413, Chengdu Medical College, corresponding author), Dai Min (0000-0002-1119-2488) |
| Year | 2026 |
| Volume | 363 |
| Pages | 121450 |
| Publication date | 2026-05-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2026.121450 |
| PMID | 41785727 |
| OpenAlex | W7133337758 |
| Language | EN |
| References cited | 49 |
HDW exerts significant antifibrotic effects in CCl 4 -induced liver fibrosis via a gut microbiota-dependent mechanism involving the restoration of BA metabolism and the activation of the hepatic FXR/SHP/CYP7A1 axis. Given its ability to modulate gut microbial ecology, BA homeostasis and intestinal barrier integrity simultaneously, HDW is a promising therapeutic candidate for targeting the gut microbiota in the treatment of liver fibrosis
Bile acid · Carbon tetrachloride · Fibrosis · Gut flora · Hepatic fibrosis · Hepatic stellate cell · Hydroxyproline · Liver function · Sirius Red · Drug Transport and Resistance Mechanisms · Liver Disease Diagnosis and Treatment · Liver physiology and pathology
| Citation velocity | historical |
|---|---|
| Highly cited | No |