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Xiao-Chaihu-Tang preserves intestinal barrier and ameliorates irinotecan-evoked delayed diarrhea by anchoring endogenous tryptophol to modulate inflammation and oxidation dependent on AhR-UGT1A1-microbiota axis

Bibliographic Data

ID14739784
AuthorsQiulong Zhao (0000-0002-4419-3305, Guangzhou University of Chinese Medicine), Yuanyuan Cao (0000-0001-7709-6862, Sun Yat-sen University), Lin Zhang (0000-0001-5966-3827, Guangzhou University of Chinese Medicine), Zhenyi Zhang (0000-0003-3606-8966, Guangzhou University of Chinese Medicine), Yang Yang (0000-0002-3705-7612, Guangzhou University of Chinese Medicine), Li Wang (0000-0002-3460-2080, Guangzhou University of Chinese Medicine, corresponding author), Min Xu (0000-0002-8940-1614, Nanjing University of Chinese Medicine), Yaqing Mao (0000-0002-8576-6974, Nanjing University of Chinese Medicine), Xiaohang Zhang (0000-0002-5315-8712, Nanjing University of Chinese Medicine), Min Zeng (0009-0006-3980-8666, Hubei University of Medicine), Peishan Yang (Zhongshan People's Hospital), Hui Yan (0000-0002-1204-9165, Zhongshan People's Hospital, corresponding author), Qinhua Chen (0000-0002-9108-1314, Guangzhou University of Chinese Medicine, corresponding author), Guangyi Yang (0000-0002-1482-1518, Guangzhou University of Chinese Medicine, corresponding author)
Year2026
Volume363
Pages121380
Publication date2026-05-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2026.121380
PMID41713817
OpenAlexW7129781431
LanguageEN
References cited75

Diarrhea · Endogeny · Inflammation · Intestinal mucosa · Oxidative stress · Pathogenesis · Pathophysiology · Toxicity · Cancer therapeutics and mechanisms · Drug Transport and Resistance Mechanisms · Gut microbiota and health

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