The acute toxic effect of Chinese medicine Fuzi is exacerbated in kidney yang deficiency mice due to metabolic difference

Dados Bibliográficos

ID14740488
AutoresHui Jiang (0000-0001-8393-8368, Second Affiliated Hospital of Zhejiang University), Xiaoyu Li (0000-0003-4438-9014, Second Affiliated Hospital of Zhejiang University), Fan Yang (0000-0003-2978-7102, Second Affiliated Hospital of Zhejiang University), Yang Fan (0009-0004-1290-4418), Junjie Wang (0000-0001-7953-4918, Second Affiliated Hospital of Zhejiang University), Yiyi Xie (Second Affiliated Hospital of Zhejiang University), Peilin Yu (0000-0002-8230-4061, Second Affiliated Hospital of Zhejiang University, autor correspondente)
Ano2024
Volume328
Páginas118036
Data de publicação2024-06-01
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoJournal of Ethnopharmacology (JOURNAL)
Identificadores do periódicoISSN: 0378-8741 • E-ISSN: 1872-7573
EditoraElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2024.118036
PMID38460575
OpenAlexW4392592022
IdiomaEN
Citações recebidas2
Referências citadas13

In conclusion, our study showed that changes of the metabolic enzyme activity in individuals with different syndromes led to different toxic effects of Chinese medicines, emphasizing the crucial importance of considering individual physical syndromes in the clinical application of traditional Chinese medicine, and the significance of conducting safety evaluations and dose predictions on animal models with specific syndromes for traditional Chinese medicines

CYP3A4 · Cytochrome P450 · Kidney · Kidney disease · Metabolism · Pathology · Toxicity · Traditional Chinese medicine · Traditional medicine · Bioactive Natural Diterpenoids Research · Medicine · Pharmacological Effects of Natural Compounds · Plant-based Medicinal Research · Internal Medicine · Pharmacology