A novel phthalein component ameliorates neuroinflammation and cognitive dysfunction by suppressing the CXCL12/CXCR4 axis in rats with vascular dementia

Bibliographic Data

ID14740904
AuthorsKai-Ting Ma (0009-0003-6933-3970, Sichuan University), Yi-Jin Wu (0000-0002-6169-9084, Sichuan University), Yuxin Yang (0009-0005-4068-9644, West China Medical Center of Sichuan University), Yu-Xin Yang, Ting Wu (0000-0002-2169-4334, Sichuan University), Chu Chen (0000-0003-3619-9202, Sichuan Academy of Traditional Chinese Medicine), Peng Fu (0009-0009-6501-1556, Sichuan University), Fu Peng (0000-0003-0289-4426), Junrong Du (0000-0003-3320-5785, Sichuan University, corresponding author), Jun-rong Du, Cheng Peng (0000-0002-3770-586X, Chengdu University of Traditional Chinese Medicine, corresponding author)
Year2024
Volume328
Pages118117
Publication date2024-06-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2024.118117
PMID38548120
OpenAlexW4393187570
LanguageEN
Citations received1
References cited54

QBT effectively mitigated neuronal damage and cognitive dysfunction in VaD rats, exerting neuroprotective effects by suppressing neuroinflammatory response through inhibition of the CXCL12/CXCR4 axis

Biology · Chemokine · Dementia · Hippocampus · Inflammation · Microglia · Morris water navigation task · Neuroinflammation · Neuroprotection · PI3K/AKT/mTOR pathway · Protein kinase B · Signal transduction · Vascular dementia · Chemistry · Medicine · Neuroinflammation and Neurodegeneration Mechanisms · Neurological Disease Mechanisms and Treatments · Neurological disorders and treatments · Cell Biology · Immunology · Internal Medicine · Pharmacology