A standardized herbal combination of Astragalus membranaceus and Paeonia japonica, protects against muscle atrophy in a C26 colon cancer cachexia mouse model
Bibliographic Data
| ID | 14741018 |
|---|---|
| Authors | Sung-Bae Lee, Sung Bae Lee (0000-0002-8980-6769, Daejeon University), Jinseok Lee (0000-0002-8580-490X, Daejeon University), Jin-Seok Lee (0000-0002-4194-6025), Sung-Ok Moon (National Development Institute of Korean Medicine), Hwa-Dong Lee (0000-0001-8734-9325, National Development Institute of Korean Medicine), Yoosik Yoon (0000-0002-9823-4555, Chung-Ang University), Yoo-Sik Yoon, Chang-Gue Son, Chang‐Gue Son (0000-0002-6963-5229, Daejeon University, corresponding author) |
| Year | 2021 |
| Volume | 267 |
| Pages | 113470 |
| Publication date | 2021-03-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2020.113470 |
| PMID | 33068652 |
| OpenAlex | W3093257725 |
| Language | EN |
| Citations received | 8 |
| References cited | 50 |
Our data indicate the potential of an herbal formula, APX as an anti-cachexia agent; the effect of APX was superior to that of megestrol acetate overall especially for muscle atrophy. The underlying mechanisms of this herbal formula may involve the modulation of muscle atrophy-promoting molecules including p38, NFκB, TNF-α and TWEAK
Astragalus · Atrophy · Cachexia · Cancer · Colorectal cancer · Pathology · Phytotherapy · Traditional Chinese medicine · Traditional medicine · Diet and metabolism studies · Medicine · Muscle Physiology and Disorders · Nutrition and Health in Aging · Internal Medicine · Pharmacology
Anti-obesity effect of Lactobacillus fermented Paeonia japonica, Cnidium officinale, and Angelica gigas nakai
The immune-enhancing effects of a mixture of Astragalus membranaceus (Fisch.) Bunge, Angelica gigas Nakai, and Trichosanthes Kirilowii (Maxim.) or its active constituent nodakenin
Sijunzi decoction alleviates cancer cachexia myatrophy by suppressing M2 polarization of tumor-associated macrophages via the MCT1/lactate/H3K18 lactylation pathway
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Tinglu Yixin granule inhibited fibroblast-myofibroblast transdifferentiation to ameliorate myocardial fibrosis in diabetic mice
Fuzheng Xiaoai Decoction 1 ameliorated cancer cachexia-induced muscle atrophy via Akt-mTOR pathway
Yiqi Yangxue formula inhibits cartilage degeneration in knee osteoarthritis by regulating LncRNA-UFC1/miR-34a/MMP-13 axis
Antidepressant potential of total flavonoids from Astragalus in a chronic stress mouse model
Astragalus polysaccharides decrease muscle wasting through Akt/mTOR, ubiquitin proteasome and autophagy signalling in 5/6 nephrectomised rats
Modified Sijunzi decoction can alleviate cisplatin-induced toxicity and prolong the survival time of cachectic mice by recovering muscle atrophy
Formononetin, an isoflavone from Astragalus membranaceus inhibits proliferation and metastasis of ovarian cancer cells
Synergistic hepatoprotective effects of CGplus on CCl4-induced acute injury
Paeonia lactiflora root extract suppresses cancer cachexia by down-regulating muscular NF-κB signalling and muscle-specific E3 ubiquitin ligases in cancer-bearing mice
| Unique citing works | 8 |
|---|---|
| Citations per year | 2 |
| Citation span | 2022 - 2026 (5) |
| Citation velocity | current |
| Highly cited | No |
| Citation types | Neutral: 8 |