Raddeanin A suppresses intracellular 5Methylcytosine DNA modification engaged the metastasis of hepatocellular carcinoma
Bibliographic Data
| ID | 14743019 |
|---|---|
| Authors | Xin Liu (0000-0001-5207-1685, Chinese Academy of Sciences), Xiaoyan Xie (0000-0003-1757-8872, Changchun University of Chinese Medicine), Kangyu Wang (0000-0003-0580-1395, Shanghai University of Traditional Chinese Medicine), Xiaokang Liu (0000-0001-8478-3740), Xiao‐Kang Liu (0000-0001-6262-6779, Chinese Academy of Sciences), Jiyu Gong (0000-0001-8573-1870, Changchun University of Chinese Medicine), Zizhao Yang (0000-0002-9602-0764, Shanghai University of Traditional Chinese Medicine, corresponding author), Jiannan Li (0009-0000-6960-9111, Changchun University of Chinese Medicine) |
| Year | 2025 |
| Volume | 338 |
| Issue | Pt 2 |
| Pages | 119036 |
| Publication date | 2025-02-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2024.119036 |
| PMID | 39515681 |
| OpenAlex | W4404094027 |
| Language | EN |
| References cited | 32 |
The RA compound acts as an antagonist against HCC by reducing intracellular DNA 5 mC levels through mechanisms mediated by methyltransferase. Moreover, RA demonstrates the capacity to induce apoptosis in tumor cells, thereby exerting its anti-tumor effects. The findings of this study provide valuable insights for enhancing the pharmacodynamic efficacy of RA in HCC treatment
Biological activity · Biology · Cancer · Carcinoma · Hepatocellular carcinoma · In vitro · Intracellular · Metastasis · Pharmacognosy · Traditional medicine · DNA Repair Mechanisms · Epigenetics and DNA Methylation · Medicine · RNA modifications and cancer · Cancer Research · Genetics · Internal Medicine · Oncology
| Citation velocity | historical |
|---|---|
| Highly cited | No |