Uncovering the key pharmacodynamic material basis and possible molecular mechanism of Xiaoke formulation improve insulin resistant through a comprehensive investigation
Bibliographic Data
| ID | 14743157 |
|---|---|
| Authors | Wenjuan Ma (0000-0001-8637-0800, Shenyang Pharmaceutical University), Jianglan Long (Beijing Friendship Hospital), Linjie Dong (Shenyang Pharmaceutical University), Jian Zhang (0000-0001-7681-8747, Chengdu University of Traditional Chinese Medicine), Aiting Wang (0000-0003-2723-888X, Beijing Friendship Hospital), Yu Zhang (0000-0002-0059-270X, Beijing Friendship Hospital, corresponding author), Dan Yan (0000-0003-1219-9646, Beijing Friendship Hospital, corresponding author) |
| Year | 2024 |
| Volume | 323 |
| Pages | 117752 |
| Publication date | 2024-04-01 |
| Peer Reviewed | Yes |
| Open Access | Yes |
| Type | ARTICLE |
| Venue | Journal of Ethnopharmacology (JOURNAL) |
| Journal identifiers | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Publisher | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2024.117752 |
| PMID | 38216099 |
| OpenAlex | W4390806134 |
| Language | EN |
| Citations received | 1 |
| References cited | 33 |
The key pharmacodynamic material basis of XKF, such as berberine and its metabolites (berberrubine and demethyleneberberine), chlorogenic acid and its metabolites (3-O-feruloylquinic acid and 5-O-feruloylquinic acid), calycosin and swertiamarin influence the glucose metabolism disorder of IR-HepG2 cells by regulating the PI3K/AKT signalling pathway, leading to an improvement in IR
Berberine · Bioinformatics · Biology · Insulin · Insulin receptor · Insulin resistance · Metabolome · Metabolomics · Pharmacodynamics · Pharmacokinetics · PI3K/AKT/mTOR pathway · Protein kinase B · Signal transduction · Berberine and alkaloids research · Chemistry · Chromatography in Natural Products · Traditional Chinese Medicine Analysis · Biochemistry · Endocrinology · Pharmacology
Retracted
Anemarrhena saponins attenuate insulin resistance in rats with high-fat diet-induced obesity via the IRS-1/PI3K/AKT pathway
A Chinese medicine formula (Jinqi Jiangtang Tablet)
A refined-JinQi-JiangTang tablet ameliorates prediabetes by reducing insulin resistance and improving beta cell function in mice
A diarylheptanoid compound from Alpinia officinarum Hance ameliorates high glucose-induced insulin resistance by regulating PI3K/AKT-Nrf2-GSK3β signaling pathways in HepG2 cells
Network pharmacology strategy for revealing the pharmacological mechanism of pharmacokinetic target components of San-Ye-Tang-Zhi-Qing formula for the treatment of type 2 diabetes mellitus
| Unique citing works | 1 |
|---|---|
| Citations per year | 0,5 |
| Citation span | 2024 - 2024 (1) |
| Citation velocity | recent |
| Highly cited | No |
| Citation types | Neutral: 1 |