Screening of Zulu medicinal plants for angiotensin converting enzyme (ACE) inhibitors

Bibliographic Data

ID14744158
AuthorsAndrew C Duncan, Alfonso Patricio Cajas Palacios (corresponding author), Anna K Jäger (0000-0002-3644-8208), Jorge Miguel Solano Quezada, J Van Staden (0000-0003-0515-1281)
Year1999
Volume68
Issue1-3
Pages63-70
Publication date1999-12-01
Peer ReviewedYes
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/s0378-8741(99)00097-5
OpenAlexW10624863
LanguageEN
Citations received17
References cited7

Twenty plants used by traditional healers in South Africa for the treatment of high blood pressure were investigated for their anti-hypertensive properties, utilizing the angiotensin converting enzyme assay. A hit rate of 65% was achieved, with the highest inhibition (97%) obtained by Adenopodia spicata leaves. A further seven plants exhibited an inhibition greater than 70% and five more over 50%. The leaves of the plants showed the greatest levels of inhibition. There was little difference in the overall hit rate between ethanolic and aqueous extracts, although in most cases there was a marked difference in activity between aqueous and ethanolic extracts from the same species. Plants exhibiting inhibition levels greater than 50% were further tested for the presence of tannins in order to eliminate possible false positives. Active plants that did not contain tannins were Agapanthus africanus, Agave americana, Clausena anisata, Dietes iridioides, Mesembruanthemum spp., Stangeria eriopus and Tulbaghia violacea

Art · Cartography · Geography · Humanities · Aging, Health, and Disability · Latin American Urban Studies · Occupational Health and Safety in Workplaces

Tools

Open DOISci-Hub