Fractionation and identification of ocular protective compounds from kochiae fructus against oxidative damage in retinal pigment epithelium cells

Bibliographic Data

ID14744252
AuthorsJian-Sheng Wu (0000-0003-2497-6633), Jian‐Sheng Wu (China Medical University), Pei-Yi Chu, Pei‐Yi Chu (0000-0001-7336-2465, China Medical University), Wei-Yu Hsu (China Medical University), Ta-Hsien Chuang, Ta‐Hsien Chuang (China Medical University), Ying-Chun Yu, Yingchun Yu (China Medical University), Yicheng Pan (0000-0003-4918-3808, China Medical University), Yi-Cheng Pan, Yi-Ting Lin (0000-0003-3821-4744, China Medical University), Chih-Hsin Tang, Chih‐Hsin Tang (0000-0002-7113-8352, China Medical University), Chia-Lin Lee (0000-0003-2679-9001, China Medical University, corresponding author), Yang‐Chang Wu (0000-0001-7815-2686, China Medical University, corresponding author), Yang-Chang Wu
Year2025
Volume341
Pages119328
Publication date2025-02-01
Open AccessYes
TypeARTICLE
VenueJournal of Ethnopharmacology (JOURNAL)
Journal identifiersISSN: 0378-8741 • E-ISSN: 1872-7573
PublisherElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2025.119328
PMID39793774
OpenAlexW4406229986
LanguageEN
References cited55

The protective effects of Kochiae Fructus against oxidative damage in RPE cell was validated with the KSEM fraction. The compound quercetin was identified as the important contributor. However, the synergistic effect of the hyperoside, quercetin, and kaempferol mixture may play a dominant role in the protective action of Kochiae Fructus. Overall, these findings highlight the potential of Kochiae Fructus and its flavonol mixture as a basis for developing treatments targeting ocular diseases associated with oxidative damage in retina

Antioxidant · Apoptosis · Chromatography · Ethyl acetate · Flavonols · Hyperoside · Kaempferol · Oxidative stress · Programmed cell death · Quercetin · Chemistry · Essential Oils and Antimicrobial Activity · Medicine · Phytochemistry and Biological Activities · Traditional Chinese Medicine Analysis · Biochemistry · Pharmacology

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